Glipalamide (Glipolamid) is a hypoglycemic agent and part of the second-generation sulfonamide derivatives. These sulphonylureas are used as medication to control blood sugar levels in patients with diabetes type 2. Like other sulphonylureas, glipalamide exerts extra-pancreatic activity. The antihyperglycemic action of this compound (and other sulphonylureas) may be explained by increased affinity of insulin receptors and the stimulating action of these compounds on peripheral glucose metabolism. Glipalamide was analyzed for its physical-chemical properties. After oral administration in animals, no differences were observed in insulin concentration between experimental and control groups, despite a significant fall in blood glucose level.