β-Estradiol 17-acetate is a natural metabolite of estradiol. Hydrolytic enzymes in human cadaver, hairless dog, rat and hairless mouse skin can metabolize β-Estradiol 17-acetate to β-Estradiol. β-Estradiol 17-acetate transported across the human and hairless dog skin can be effectively metabolized before entering the capillary.

2-Ethoxyethyl acetate (2-EEA) is a colourless liquid with a fruity smell at room temperature and normal pressure. 2-Ethoxyethyl acetate belongs to the group of glycol ethers which are mainly used as solvents. 2-EEA was mainly used as a solvent in the chemical industry and for the formulation of paints, lacquers and varnishes for industrial use. 2-EEA was also used as an intermediate in the chemical industry.