2-ETHOXYETHYL ACETATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H12O3
Molecular Weight	132.1577
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOCCOC(C)=O

InChI

InChIKey=SVONRAPFKPVNKG-UHFFFAOYSA-N

InChI=1S/C6H12O3/c1-3-8-4-5-9-6(2)7/h3-5H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C6H12O3
Molecular Weight	132.1577
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://echa.europa.eu/documents/10162/d02e2d1c-0f53-4cf6-aec8-f1697fcf2db3

2-Ethoxyethyl acetate (2-EEA) is a colourless liquid with a fruity smell at room temperature and normal pressure. 2-Ethoxyethyl acetate belongs to the group of glycol ethers which are mainly used as solvents. 2-EEA was mainly used as a solvent in the chemical industry and for the formulation of paints, lacquers and varnishes for industrial use. 2-EEA was also used as an intermediate in the chemical industry.

CNS Activity

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Developmental toxicity of four glycol ethers applied cutaneously to rats.	1984 Aug	6499820
Developmental toxicity evaluation of inhaled 2-ethoxyethanol acetate in Fischer 344 rats and New Zealand white rabbits.	1988 Jan	3350227
Proposed occupational exposure limits for select ethylene glycol ethers using PBPK models and Monte Carlo simulations.	2001 Jul	11399800
Seasonal patterns of non-terpenoid C6-C10 VOC emission from seven Mediterranean woody species.	2001 Oct	11592412
Field evaluation of a passive sampler for assessing 2-ethoxyethyl acetate exposures.	2004 Nov	15613771
Hematological follow-up of an intervention program adding rubber glove-wearing to local ventilation for 2-ethoxyethanol acetate-exposed workers.	2007 Jul	17690522
Assessment of airborne and dermal exposure to 2-ethoxyethyl acetate in an occupational environment.	2009 Aug	19507184
Localized fetomaternal hyperglycemia: spatial and kinetic definition by positron emission tomography.	2010 Aug 6	20700464
Occupational reproductive function abnormalities and bladder cancer in Korea.	2010 Dec	21258590
Spatial distribution of sequential ventilation during mechanical ventilation of the uninjured lung: an argument for cyclical airway collapse and expansion.	2010 May 5	20444262

Patents

Sample Use Guides

In Vivo Use Guide

Male beagle dogs were exposed to 50 ppm 2-Ethoxyethyl acetate for 5 hr, and breath samples were collected during the exposure and a 3-hr recovery period. After IV dosing with 1 mg/kg of 2-Ethoxyethyl acetate the urine contained 20% and 61% of the dose in 4 and 24 hr, respectively.

Route of Administration: Other

In Vitro Use Guide

The rate of absorption of 2-ethoxyethyl acetate across isolated human abdominal epidermis was 0.800 mg/cm2/hr.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:11:32 GMT 2023` Edited by `admin` on `Fri Dec 15 19:11:32 GMT 2023`
Record UNII	DG1O0Z7390
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

2-ETHOXYETHYL ACETATE

Systematic Name

English

2-ETHOXYETHANOL 1-ACETATE

Common Name

English

NSC-8658

Code

English

ETHYLENE GLYCOL MONOETHYL ETHER ACETATE [HSDB]

Common Name

English

2-ETHOXYETHYL ACETATE [MI]

Common Name

English

ETHOXYETHANOL ACETATE

Official Name

English

ETHOXYETHANOL ACETATE [INCI]

Common Name

English

CELLOSOLVE ACETATE

Common Name

English

ETHYLENE GLYCOL MONOETHYL ETHER ACETATE

Systematic Name

English

Code System Code Type Description

NSC

8658