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Details

Stereochemistry ACHIRAL
Molecular Formula C6H12O3
Molecular Weight 132.1577
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 2-ETHOXYETHYL ACETATE

SMILES

CCOCCOC(C)=O

InChI

InChIKey=SVONRAPFKPVNKG-UHFFFAOYSA-N
InChI=1S/C6H12O3/c1-3-8-4-5-9-6(2)7/h3-5H2,1-2H3

HIDE SMILES / InChI

Description

2-Ethoxyethyl acetate (2-EEA) is a colourless liquid with a fruity smell at room temperature and normal pressure. 2-Ethoxyethyl acetate belongs to the group of glycol ethers which are mainly used as solvents. 2-EEA was mainly used as a solvent in the chemical industry and for the formulation of paints, lacquers and varnishes for industrial use. 2-EEA was also used as an intermediate in the chemical industry.

CNS Activity

CNS Active
4002
Curator's Comment: May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea.

Approval Year

Unknown
149124
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Occupational reproductive function abnormalities and bladder cancer in Korea.
2010-12
Localized fetomaternal hyperglycemia: spatial and kinetic definition by positron emission tomography.
2010-08-06
Spatial distribution of sequential ventilation during mechanical ventilation of the uninjured lung: an argument for cyclical airway collapse and expansion.
2010-05-05
Assessment of airborne and dermal exposure to 2-ethoxyethyl acetate in an occupational environment.
2009-08
Hematological follow-up of an intervention program adding rubber glove-wearing to local ventilation for 2-ethoxyethanol acetate-exposed workers.
2007-07
Field evaluation of a passive sampler for assessing 2-ethoxyethyl acetate exposures.
2004-11
Final report on the safety assessment of ethoxyethanol and ethoxyethanol acetate.
2002
Seasonal patterns of non-terpenoid C6-C10 VOC emission from seven Mediterranean woody species.
2001-10
Proposed occupational exposure limits for select ethylene glycol ethers using PBPK models and Monte Carlo simulations.
2001-07
Developmental toxicity evaluation of inhaled 2-ethoxyethanol acetate in Fischer 344 rats and New Zealand white rabbits.
1988-01
Developmental toxicity of four glycol ethers applied cutaneously to rats.
1984-08
Patents

Patents

06313245
2
06362379
2
JP2001026725A
1
JP2003147277A
1
JP2004231554A
4
JP2004318111A
5
JP2010254920A
1
JPH0616976A
1
JPH07909A
1
JPH10245548A
1
JPS54103812A
1
JPS54151459A
1
JPS58224440A
1
JPS60154248A
1
JPS60177078A
1

Sample Use Guides

In Vivo Use Guide
Male beagle dogs were exposed to 50 ppm 2-Ethoxyethyl acetate for 5 hr, and breath samples were collected during the exposure and a 3-hr recovery period. After IV dosing with 1 mg/kg of 2-Ethoxyethyl acetate the urine contained 20% and 61% of the dose in 4 and 24 hr, respectively.
Route of Administration: Other
In Vitro Use Guide
The rate of absorption of 2-ethoxyethyl acetate across isolated human abdominal epidermis was 0.800 mg/cm2/hr.
Name Type Language
2-ETHOXYETHYL ACETATE
MI  
Systematic Name English
ETHOXYETHANOL ACETATE
INCI  
INCI  
Preferred Name English
2-ETHOXYETHANOL 1-ACETATE
Common Name English
NSC-8658
Code English
ETHYLENE GLYCOL MONOETHYL ETHER ACETATE [HSDB]
Common Name English
2-ETHOXYETHYL ACETATE [MI]
Common Name English
CELLOSOLVE ACETATE
Common Name English
ETHYLENE GLYCOL MONOETHYL ETHER ACETATE
HSDB  
Systematic Name English
Code System Code Type Description
NSC
8658
Created by admin on Mon Mar 31 19:34:59 GMT 2025 , Edited by admin on Mon Mar 31 19:34:59 GMT 2025
PRIMARY
EPA CompTox
DTXSID9021928
Created by admin on Mon Mar 31 19:34:59 GMT 2025 , Edited by admin on Mon Mar 31 19:34:59 GMT 2025
PRIMARY
ECHA (EC/EINECS)
203-839-2
Created by admin on Mon Mar 31 19:34:59 GMT 2025 , Edited by admin on Mon Mar 31 19:34:59 GMT 2025
PRIMARY
HSDB
539
Created by admin on Mon Mar 31 19:34:59 GMT 2025 , Edited by admin on Mon Mar 31 19:34:59 GMT 2025
PRIMARY
PUBCHEM
8095
Created by admin on Mon Mar 31 19:34:59 GMT 2025 , Edited by admin on Mon Mar 31 19:34:59 GMT 2025
PRIMARY
CAS
111-15-9
Created by admin on Mon Mar 31 19:34:59 GMT 2025 , Edited by admin on Mon Mar 31 19:34:59 GMT 2025
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MERCK INDEX
m5074
Created by admin on Mon Mar 31 19:34:59 GMT 2025 , Edited by admin on Mon Mar 31 19:34:59 GMT 2025
PRIMARY Merck Index
WIKIPEDIA
2-Ethoxyethyl acetate
Created by admin on Mon Mar 31 19:34:59 GMT 2025 , Edited by admin on Mon Mar 31 19:34:59 GMT 2025
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SMS_ID
300000052963
Created by admin on Mon Mar 31 19:34:59 GMT 2025 , Edited by admin on Mon Mar 31 19:34:59 GMT 2025
PRIMARY
FDA UNII
DG1O0Z7390
Created by admin on Mon Mar 31 19:34:59 GMT 2025 , Edited by admin on Mon Mar 31 19:34:59 GMT 2025
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MESH
C022278
Created by admin on Mon Mar 31 19:34:59 GMT 2025 , Edited by admin on Mon Mar 31 19:34:59 GMT 2025
PRIMARY
NIH
NCATS
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