Caprospinol, also known as SP-233, a spirostenol derivative, protects neuronal cells against β-Amyloid (Abeta(1-42)) protein toxicity by binding to and inactivating this peptide. It was shown, that caprospinol crossed the blood-brain barrier, accumulated in the brain, and restored cognitive impairment in a pharmacological rat model of Alzheimer's disease. It was suggested, that the drug could be considered as a promising drug for Alzheimer's disease treatment.