Details
| Stereochemistry | MIXED |
| Molecular Formula | C23H30N2O2 |
| Molecular Weight | 366.4965 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(=O)N(C1CCN(CC(O)C2=CC=CC=C2)CC1C)C3=CC=CC=C3
InChI
InChIKey=FRPRNNRJTCONEC-UHFFFAOYSA-N
InChI=1S/C23H30N2O2/c1-3-23(27)25(20-12-8-5-9-13-20)21-14-15-24(16-18(21)2)17-22(26)19-10-6-4-7-11-19/h4-13,18,21-22,26H,3,14-17H2,1-2H3
| Molecular Formula | C23H30N2O2 |
| Molecular Weight | 366.4965 |
| Charge | 0 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Studies on synthesis and relationship between analgesic activity and receptor affinity for 3-methyl fentanyl derivatives. | 1981 May |
|
| [Studies on potent analgesics. V. Synthesis and analgesic activity of the ester derivatives of N-(1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidyl)-N-phenylpropan amide (7302)]. | 1983 Nov |
Patents
| Substance Class |
Chemical
Created
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admin
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Edited
Sat Dec 16 09:39:48 GMT 2023
by
admin
on
Sat Dec 16 09:39:48 GMT 2023
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| Record UNII |
Y8263089ZX
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| Record Status |
Validated (UNII)
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DEA NO. |
9831
Created by
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WIKIPEDIA |
List_of_fentanyl_analogues
Created by
admin on Sat Dec 16 09:39:48 GMT 2023 , Edited by admin on Sat Dec 16 09:39:48 GMT 2023
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| Code System | Code | Type | Description | ||
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DB01570
Created by
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PRIMARY | |||
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OHMEFENTANYL
Created by
admin on Sat Dec 16 09:39:48 GMT 2023 , Edited by admin on Sat Dec 16 09:39:48 GMT 2023
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PRIMARY | Ohmefentanyl has three stereogenic centers and eight stereoisomers, which are named F9201-F9208. Researchers are studying the different pharmaceutical properties of these isomers. The 4"-fluoro analogue (i.e. substituted on the phenethyl ring) of the 3R,4S,.BETA.S isomer of ohmefentanyl is one of the most potent opioid agonists yet discovered, possessing an analgesic potency approximately 18,000-fold greater than morphine. Other analogues with potency higher than that of ohmefentanyl itself include the 2'-fluoro derivative (i.e. substituted on the aniline phenyl ring), and derivatives where the N-propionyl group was replaced by N-methoxyacetyl or 2-furamide groups, or a carboethoxy group is added to the 4-position of the piperidine ring. The latter is listed as being up to 30,000 times more potent than morphine. | ||
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62279
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DTXSID50868495
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Y8263089ZX
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78995-14-9
Created by
admin on Sat Dec 16 09:39:48 GMT 2023 , Edited by admin on Sat Dec 16 09:39:48 GMT 2023
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PRIMARY |
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SALT/SOLVATE -> PARENT |
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
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TARGET -> AGONIST |
IC50 of Fentanyl= 1.23 NM
IC50
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ACTIVE MOIETY |
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