U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 3031 - 3040 of 4432 results

Status:
Possibly Marketed Outside US
Source:
Japan:Sodium Glucuronate
Source URL:
First approved in 2023
Source:
Florafol FE Pediatric 0.25 mg/mL Multivitamin and Fluoride Liquid Drops by Pangea Pharmaceuticals, LLC
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Glucuronic acid (α-D-GLUCURONIC ACID) is a carboxylic acid that has the structure of a glucose molecule that has had its sixth carbon atom (of six total) oxidized. The salts of glucuronic acid are known as glucuronates. Glucuronic acid is highly soluble in water. In humans, glucuronic acid is often linked to toxic or poisonous substances to allow for subsequent elimination, and to hormones to allow for easier transport. These linkages involve O-glycosidic bonds. The process is known as glucuronidation, and the resulting substances are known as glucuronides (or glucuronosides). Glucuronidation uses UDP-glucuronic acid (glucuronic acid linked via a glycosidic bond to uridine diphosphate) as an intermediate. UDP-glucuronic acid is formed in the liver of all animals. α-D-GLUCURONIC ACID is used as pharmaceutical intermediate and in chemical research.
Status:
Possibly Marketed Outside US
First approved in 2022
Source:
PROTECT CARDIO AF by GIL Pharmaceutical Corp.
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Conditions:

Tocotrienols are a group of chemicals that are part of the vitamin E family. Tocotrienol is any of the four forms, alpha, beta, gamma and delta, of a member of the vitamin E family. It has potential hypocholesterolemic, antithrombotic, antioxidant, immunomodulating and antineoplastic activities. Tocotrienol inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, thereby lowering cholesterol levels. In addition, tocotrienol acts through multiple signal transduction pathways to induce cell cycle arrest and caspase-mediated apoptosis, and to decrease tumor cell proliferation. In addition, this agent may inhibit angiogenesis through the blockage of vascular endothelial growth factor receptor (VEGFR) and the subsequent inhibition of tumor cell-induced vessel formation. Also, this agent prevents free radical formation and inhibits lipid peroxidation, thereby preventing DNA cell damage. Tocotrienols are scare in nature. They are found most abundantly in crude palm oil extracted from palm fruits. Other sources are rice bran, wheat germ, oat and barley. These substances are available in supplement form as capsules or pills.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Cedryl acetate is widely used as the aroma in daily chemicals (content less than 20%). It also can be used in food approved by FDA but not more than 1m/kg. It was shown, that cedryl acetate possesses α-glucosidase inhibitory activity.

Showing 3031 - 3040 of 4432 results