U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C6H10O7
Molecular Weight 194.1394
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of .ALPHA.-D-GLUCURONIC ACID

SMILES

O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O

InChI

InChIKey=AEMOLEFTQBMNLQ-WAXACMCWSA-N
InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6-/m0/s1

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including http://www.hmdb.ca/metabolites/hmdb00127 and https://www.ncbi.nlm.nih.gov/mesh/68020723

Glucuronic acid (α-D-GLUCURONIC ACID) is a carboxylic acid that has the structure of a glucose molecule that has had its sixth carbon atom (of six total) oxidized. The salts of glucuronic acid are known as glucuronates. Glucuronic acid is highly soluble in water. In humans, glucuronic acid is often linked to toxic or poisonous substances to allow for subsequent elimination, and to hormones to allow for easier transport. These linkages involve O-glycosidic bonds. The process is known as glucuronidation, and the resulting substances are known as glucuronides (or glucuronosides). Glucuronidation uses UDP-glucuronic acid (glucuronic acid linked via a glycosidic bond to uridine diphosphate) as an intermediate. UDP-glucuronic acid is formed in the liver of all animals. α-D-GLUCURONIC ACID is used as pharmaceutical intermediate and in chemical research.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Inactivation of Corynebacterium glutamicum NCgl0452 and the role of MgtA in the biosynthesis of a novel mannosylated glycolipid involved in lipomannan biosynthesis.
2007 Feb 16
A sulfated glucuronofucan containing both fucofuranose and fucopyranose residues from the brown alga Chordaria flagelliformis.
2008 Oct 13
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
.ALPHA.-D-GLUCURONIC ACID
Common Name English
.ALPHA.-D-GLUCOPYRANOSYLURONIC ACID
Common Name English
.ALPHA.-D-GLUCOPYRANURONIC ACID
Common Name English
GLUCURONIC ACID, ALPHA.-D-
Common Name English
Code System Code Type Description
PUBCHEM
444791
Created by admin on Sat Dec 16 10:00:48 GMT 2023 , Edited by admin on Sat Dec 16 10:00:48 GMT 2023
PRIMARY
FDA UNII
M7Y086VB5G
Created by admin on Sat Dec 16 10:00:48 GMT 2023 , Edited by admin on Sat Dec 16 10:00:48 GMT 2023
PRIMARY
EPA CompTox
DTXSID201036416
Created by admin on Sat Dec 16 10:00:48 GMT 2023 , Edited by admin on Sat Dec 16 10:00:48 GMT 2023
PRIMARY
CAS
70021-34-0
Created by admin on Sat Dec 16 10:00:48 GMT 2023 , Edited by admin on Sat Dec 16 10:00:48 GMT 2023
PRIMARY