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Search results for benzyl root_codes_WIKIPEDIA in WIKIPEDIA (approximate match)
Status:
Possibly Marketed Outside US
Source:
21 CFR 352
(2017)
Source URL:
First approved in 2017
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
21 CFR 350
(2020)
Source URL:
First approved in 2012
Source:
21 CFR 333E
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Benzyl acetate is used as a fragrance ingredient and occurs in different plants and fruits, e.g., jasmine, apple, tea, plum, wine grape. It possesses a sweet and pleasant aroma, owing to which, it finds applications in personal hygiene and health care products.
Status:
Possibly Marketed Outside US
Source:
21 CFR 333A
(2020)
Source URL:
First approved in 2012
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
Kiehls Ultra Light Daily UV Defense CC SPF 50 Anti Pollution by L'Oreal USA Products Inc
Source URL:
First approved in 2011
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Diethylamino hydroxybenzoyl hexyl benzoate (DHHB) is an organic UV filter with high absorption in the UV-A range that minimizes the overexposure of human skin to ultraviolet radiation that may lead to acute and chronic photodamage. In in vitro studies, DHHB was not shown to be mutagenic, clastogenic, or phototoxic. DHHB was approved in Europe in 2005, is also marketed in the U.S., South America, Mexico, Japan and Taiwan, and is used in concentrations up to 10% in sunscreen products, either alone or in combination with other UV absorbers. Only a minor amount of diethylamino hydroxybenzoyl hexyl benzoate will undergo percutaneous absorption and most will remain in the upper layers of the skin. Fluorescence spectroscopy showed that DHHB and avobenzone (another chemical sunscreen ingredient) interact by a static quenching mechanism and DHHB did not affect the avobenzone excited state lifetime.
Status:
Possibly Marketed Outside US
First approved in 2006
Source:
21 CFR 347
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Benzyl cinnamate (also known as Jacobson's solution) was used to treat chronic salpingitis, and in combination with vitamin A to treat cerebrovascular lesions. In addition, it is used in heavy oriental perfumes and as a fixative and as a flavoring agent.
Status:
Possibly Marketed Outside US
Source:
ANDA083231
(1973)
Source URL:
First approved in 1973
Source:
ANDA083231
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Benzyl chloride, or α-chlorotoluene, is a reactive organochlorine compound that is a widely used chemical building block. Industrially, benzyl chloride is the precursor to benzyl esters which are used as plasticizers, flavorants, and perfumes. Phenylacetic acid, a precursor to pharmaceuticals, is produced from benzyl cyanide, which is generated by treatment of benzyl chloride with sodium cyanide. Quaternary ammonium salts, used as surfactants, are readily formed by alkylation of tertiary amines with benzyl chloride. Benzyl chloride is an alkylating agent with very irritating properties to the skin. Indicative of its high reactivity (relative to alkyl chlorides), benzyl chloride reacts with water in a hydrolysis reaction to form benzyl alcohol and hydrochloric acid. In contact with mucous membranes, hydrolysis produces hydrochloric acid. Thus, benzyl chloride is a lachrymator and has been used in chemical warfare.
Status:
Possibly Marketed Outside US
Source:
21 CFR 341
(1956)
Source URL:
First approved in 1956
Source:
21 CFR 341
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Status:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Estriol acetate benzoate is a semisynthetic, steroidal estrogen. Estriol benzoate diacetate is reported as an ingredient of Holin in Japan. It is an estrogen receptor agonist.
Status:
US Approved Rx
(2020)
Source:
NDA213422
(2020)
Source URL:
First approved in 1961
Source:
CELESTONE by SCHERING
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Betamethasone and its derivatives, betamethasone sodium phosphate and betamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties, betamethasone is combined with a mineralocorticoid to manage adrenal insufficiency and is used in the form of betamethasone benzoate, betamethasone dipropionate, or betamethasone valerate for the treatment of inflammation due to corticosteroid-responsive dermatoses. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections. Betamethasone is a glucocorticoid receptor agonist. This leads to changes in genetic expression once this complex binds to the GRE. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Betamethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.Betamethasone is used for: treating certain conditions associated with decreased adrenal gland function. It is used to treat severe inflammation caused by certain conditions, including severe asthma, severe allergies, rheumatoid arthritis, ulcerative colitis, certain blood disorders, lupus, multiple sclerosis, and certain eye and skin conditions.
Status:
US Approved Rx
(2015)
Source:
ANDA205256
(2015)
Source URL:
First approved in 1940
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Estradiol an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the placenta. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (receptors, estrogen) and exhibits little estrogenic activity in estrogen-responsive tissues. Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estradiol is used for the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria). Estradiol is marketed under the brand name Climara (among others), indicated for: the treatment of moderate to severe vasomotor symptoms due to menopause, treatment of symptoms of vulvar and vaginal atrophy due to menopause, treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure and prevention of postmenopausal osteoporosis.