GSK-1614235 (mizagliflozin) is a sodium glucose co-transporter type 1 (SGLT1) inhibitor that has been investigated for treatment in type 2 diabetes. It is thought to suppress glucose absorption from the intestine in a way that is different from conventional type 2 diabetes drugs, thereby improving postprandial hyperglycemia. Phase 1 studies have been completed.

MPEP (2-methyl-6-(phenylethynyl)pyridine) was one of the first compounds found to act a selective antagonist for the metabotropic glutamate receptor subtype mGluR5. It was under development by Novartis in the late 1990's. MPEP was found to produce neuroprotective effects following acute brain injury in animals. MPEP was also found to have positive effects on animal models of depression, anxiety and morphine withdrawl.

Fluthiacet-methyl, an isourazole herbicide is applied to actively growing weeds in soybeans to control annual broadleaf weeds. Fluthiacet-methyl induced the accumulation of protoporphyrin IX in cotyledons of cotton and inhibited chlorophyll biosynthesis in cotyledons of velvetleaf and cotton.

Methyl palmoxirate, an oral hypoglycemic agent, was studied as a selective and irreversible inhibitor of the mitochondrial enzyme carnitine palmitoyltransferase and of long-chain fatty acid oxidation to treat diabetes. In addition, this compound was used to study the brain lipid metabolism by quantitative autoradiography or positron emission tomography (PET).

Primisulfuron-methyl is a urea herbicide that is used on crop and non- crop areas for the control of grass weeds and many kinds of broad-leaved weeds. Primisulfuron-methyl is a selective postemergence systemic herbicide that is rapidly absorbed by plants and transported throughout the plant roots and foliage. The herbicide works by blocking cell growth in the active growing regions of the plant. Primisulfuron-methyl is practically non-toxic by ingestion, with a reported oral LD50 of greater than 5050 mg/kg in rats. Primisulfuron-methyl is practically nontoxic to wildfowl. Both bobwhite quail and mallard ducks show a high tolerance for the compound. Primisulfuron-methyl is of low to moderate persistence in the soil environment, with a field half-life of from 4 to 60 days. A representative value is estimated to be about 30 days.

Chlorpyrifos-methyl is a broad-spectrum organophosphorous insecticide and potential toxic pollutant widely used in agriculture and effective against a wide range of insect pests in commercial importance crops. Chlorpyrifos-methyl have endocrine disruption activity, especially anti-androgenic effects and Chlorpyrifos-methyl administration leads to hepatotoxicity and neurotoxicity in mammals. The fish exposed to chlorpyrifos-methyl exhibited behavioral changes in the form of neurotoxin toxicity: less general activity than control group, loss of equilibrium, erratic swimming and staying motionless at a certain location