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Showing 21 - 22 of 22 results

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CHLORPROGUANIL HYDROCHLORIDE

6T04V14CU9

Search for Structure

Status:

Possibly Marketed Outside US

Source:

NCT00119145: Phase 4 Interventional Completed Malaria

(2005)

Source URL:

https://clinicaltrials.gov/ct2/show/NCT00119145

Class (Stereo):

CHEMICAL (ACHIRAL)

Chlorproguanil is a biguanide. Chlorproguanil is active against P. falciparum and P. malariae. Chlorproguanil acts by inhibition of dihydrofolate reductase after cytochrome P450-catalysed cyclization. Chlorproguanil combined with dapsone was developing for the treatment of falciparum malaria. The anti-malarial combination chloroproguanil and dapsone has been withdrawn following demonstration of post-treatment haemolytic anaemia in glucose-6-phosphate dehydrogenase (G6PD) deficient patients in a phase III clinical trial.

CHLORPROGUANIL

8O3249M729

Search for Structure

Status:

Possibly Marketed Outside US

Source:

NCT00119145: Phase 4 Interventional Completed Malaria

(2005)

Source URL:

https://clinicaltrials.gov/ct2/show/NCT00119145

Class (Stereo):

CHEMICAL (ACHIRAL)

Chlorproguanil is a biguanide. Chlorproguanil is active against P. falciparum and P. malariae. Chlorproguanil acts by inhibition of dihydrofolate reductase after cytochrome P450-catalysed cyclization. Chlorproguanil combined with dapsone was developing for the treatment of falciparum malaria. The anti-malarial combination chloroproguanil and dapsone has been withdrawn following demonstration of post-treatment haemolytic anaemia in glucose-6-phosphate dehydrogenase (G6PD) deficient patients in a phase III clinical trial.

Structure of CHLORPROGUANIL HYDROCHLORIDE

ACHIRAL

CHLORPROGUANIL HYDROCHLORIDE

Structure of CHLORPROGUANIL

ACHIRAL

Showing 21 - 22 of 22 results

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