Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C11H15Cl2N5.ClH |
| Molecular Weight | 324.637 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC(C)NC(=N)NC(=N)NC1=CC(Cl)=C(Cl)C=C1
InChI
InChIKey=SVJMILFDDBKCGG-UHFFFAOYSA-N
InChI=1S/C11H15Cl2N5.ClH/c1-6(2)16-10(14)18-11(15)17-7-3-4-8(12)9(13)5-7;/h3-6H,1-2H3,(H5,14,15,16,17,18);1H
Chlorproguanil is a biguanide. Chlorproguanil is active against P. falciparum and P. malariae. Chlorproguanil acts by inhibition of dihydrofolate reductase after cytochrome P450-catalysed cyclization. Chlorproguanil combined with dapsone was developing for the treatment of falciparum malaria. The anti-malarial combination chloroproguanil and dapsone has been withdrawn following demonstration of post-treatment haemolytic anaemia in glucose-6-phosphate dehydrogenase (G6PD) deficient patients in a phase III
clinical trial.
Originator
Approval Year
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NCI_THESAURUS |
C277
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6001-93-0
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1568084
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m3460
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SUB01253MIG
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227-846-5
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DTXSID00892386
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Chlorproguanil hydrochloride
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100000092716
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C78096
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DBSALT002176
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6T04V14CU9
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15537-76-5
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CHEMBL1213553
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22322
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ACTIVE MOIETY
SUBSTANCE RECORD
