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Restrict the search for
nicotine
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
(1'R,2'S)-nicotine-1'-N-oxide is a stereoisomer of nicotine-1'-N-oxide, an oxidation product of S-(-)-nicotine. N-1'-oxidation of nicotine is mediated via flavin-containing monooxygenase. A marked stereoselectivity has been observed in the formation of N-1'-oxide metabolites from nicotine. Mammal hepatic preparations generally produce more the N-1'R,2'S-cis diastereoisomer than N-1'S,2'S-trans diastereoisomer after incubation with S-(-)-nicotine. cis- and trans-nicotine-N'-oxides modulate the development of tumors in rats initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
(1'S,2'S)-nicotine-1'-N-oxide is a stereoisomer of nicotine-1'-N-oxide, an oxidation product of S-(-)-nicotine. N-1'-oxidation of nicotine is mediated via flavin-containing monooxygenase. A marked stereoselectivity has been observed in the formation of N-1'-oxide metabolites from nicotine. Mammal hepatic preparations generally produce more the N-1'R,2'S-cis diastereoisomer than N-1'S,2'S-trans diastereoisomer after incubation with S-(-)-nicotine. (1'S,2'S)-nicotine-1'-N-oxide was reported to bind alpha3beta4 neuronal nicotinic acetylcholine receptor. cis- and trans-nicotine-N'-oxides modulate the development of tumors in rats initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
N‑Nitrosonornicotine (NNN) is a nitrosamine compound. It is produced by nitrosation of nicotine during the curing, aging, processing, and smoking of tobacco. About half of the NNN originates in the unburnt tobacco, whereas the remainder is formed during burning. NNN is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. NNN induces deleterious mutations in oncogenes and tumor suppression genes by forming DNA adducts, which could be considered as tumor initiation. Meanwhile, the binding of NNN to the nicotinic acetylcholine receptor promotes tumor growth by enhancing and deregulating cell proliferation, survival, migration, and invasion, thereby creating a microenvironment for tumor growth.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Anabasine, a tobacco alkaloid, was used as a biomarker of active tobacco use. Anabasine is a selective alpha7-nicotinic acetylcholine receptor agonist. Anabasine antagonized MK-801-elicited mouse popping behavior, an animal model of schizophrenia.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
1-methyl-4-(3-pyridinyl) pyrrole (β-nicotyrine) is a tobacco alkaloid. It is a potent inhibitor of cytochrome P450 CYP2A13 and a mechanism-based inactivator of cytochrome P450 CYP2A6.
