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Restrict the search for
hydroquinone
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Hydroquinone monoacetate (also known as 4-acetoxyphenol), an FDA-approved natural compound, was studied as a potent activator of the NRF2-ARE pathway in motor neurons and as a α-synuclein modulator that can possibly prevent or slow down the onset or progression of Parkinson's disease. In addition, was evaluated the role of 4-acetoxyphenol in age-related macular degeneration (AMD), a degenerative disorder of the central retina, which is the leading cause of irreversible central vision loss in elderly populations in developed countries. It was shown, that 4-acetoxyphenol protected human retina pigment epithelium cell lines from oxidative stress-induced necrosis through upregulation of NQO1 and HO-1 genes by stabilization of NRF2, a transcription factor and a master regulator of many antioxidant/detoxification genes. Thus, 4-Acetoxyphenol could be further evaluated for its potential use in preventing AMD progression.
