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Restrict the search for
biotin
to a specific field?
Status:
Possibly Marketed Outside US
Source:
M032
(2021)
Source URL:
First approved in 2012
Source:
21 CFR 358H
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Source:
NCT04331080: Phase 2/Phase 3 Interventional Completed Mammoplasty
(2020)
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT02075970: Phase 2 Interventional Completed Neonatal Anemia
(2014)
Source URL:
Class:
STRUCTURALLY DIVERSE
Status:
US Approved Rx
(2000)
Source:
NDA021163
(2000)
Source URL:
First approved in 1947
Source:
BEROCCA PN by ROCHE
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Biotin (also known as vitamin H and vitamin B7) is a water-soluble vitamin which is required for normal cellular functions, growth and development. Biotin is an important cofactor for many mitochondria and cytoplasm enzymes: acetyl-CoA carboxylase a (ACCa),7 ACCb, pyruvate carboxylase (PC), propionyl-CoA carboxylase (PCC), and methylcrotonyl-CoA carboxylase (MCC) and plays critical role in in the intermediate metabolism of gluconeogenesis, fatty acid synthesis, and amino acid catabolism. The vitamin cannot be synthesized by humans and must be obtained from diet. If there is a lack of biotin, an organism starts suffering from biotin deficiency, a condition which is very common among pregnant women, for example. The vitamin deficiency effects hair, nail growth and skin health. For preventing measures, biotin should be taken as a dietary supplement (in a form of vitamin complex or as a pure biotin) which are marketed worldwide under different names. Biotin is a part of many formulations which were approved by FDA.
Status:
Investigational
Source:
INN:iodine (¹³¹I) derlotuximab biotin [INN]
Source URL:
Class:
PROTEIN
Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. Iodide I-131 can be detected by gamma cameras for diagnostic imaging, however, it is rarely administered for diagnostic purposes only, imaging will normally be done following a therapeutic dose. Major uses of 131I include the treatment of thyrotoxicosis (hyperthyroidism) due to Graves' disease, and sometimes hyperactive thyroid nodules (abnormally active thyroid tissue that is not malignant). Iodine-131, in higher doses than for thyrotoxicosis, is used for ablation of remnant thyroid tissue following a complete thyroidectomy to treat thyroid cancer. The 131I isotope is also used as a radioactive label for certain radiopharmaceuticals that can be used for therapy, e.g. 131I-metaiodobenzylguanidine for imaging and treating pheochromocytoma and neuroblastoma. Because of the carcinogenicity of its beta radiation in the thyroid in small doses, I-131 is rarely used primarily or solely for diagnosis. Instead, the more purely gamma-emitting radioiodine iodine-123 is used in diagnostic testing. The longer half-lived iodine-125 is also occasionally used when a longer half-life radioiodine is needed for diagnosis, and in brachytherapy treatment, where the low-energy gamma radiation without a beta component makes iodine-125 useful.
