BIOTIN SODIUM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H15N2O3S.Na
Molecular Weight	266.292
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[H][C@]12CS[C@@H](CCCCC([O-])=O)[C@@]1([H])NC(=O)N2

InChI

InChIKey=BHSAIWYNTUBSFL-UFLZEWODSA-M

InChI=1S/C10H16N2O3S.Na/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9;/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15);/q;+1/p-1/t6-,7-,9-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C10H15N2O3S
Molecular Weight	243.303
Charge	-1
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: www.ncbi.nlm.nih.gov/pubmed/18356320
Curator's Comment: description was created based on several sources, including www.ncbi.nlm.nih.gov/pubmed/17182796, www.ncbi.nlm.nih.gov/pubmed/19056639

Biotin (also known as vitamin H and vitamin B7) is a water-soluble vitamin which is required for normal cellular functions, growth and development. Biotin is an important cofactor for many mitochondria and cytoplasm enzymes: acetyl-CoA carboxylase a (ACCa),7 ACCb, pyruvate carboxylase (PC), propionyl-CoA carboxylase (PCC), and methylcrotonyl-CoA carboxylase (MCC) and plays critical role in in the intermediate metabolism of gluconeogenesis, fatty acid synthesis, and amino acid catabolism. The vitamin cannot be synthesized by humans and must be obtained from diet. If there is a lack of biotin, an organism starts suffering from biotin deficiency, a condition which is very common among pregnant women, for example. The vitamin deficiency effects hair, nail growth and skin health. For preventing measures, biotin should be taken as a dietary supplement (in a form of vitamin complex or as a pure biotin) which are marketed worldwide under different names. Biotin is a part of many formulations which were approved by FDA.

CNS Activity

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Vitamin deficiency 17 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021163s032,021559s025lbl.pdf	Preventing		Approved 8429	INFUVITE ADULT Approved Use INFUVITE ADULT is a combination of vitamins indicated for prevention of vitamin deficiency in adults and children aged 11 and older receiving parenteral nutrition. Launch Date 2000
Biotin deficiency 2 Sources: https://cscprivatelabel.com/wp-content/uploads/2016/05/Biotin.pdf	Preventing		Approved 8429	BIOTIN Approved Use As a dietary supplement.

C_max

Value	Dose	Analyte	Population
508.5 ng/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6574044/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:	BIOTIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN
84.8 ng/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6574044/	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered:	BIOTIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN
494.9 ng/mL REVIEW https://pubmed.ncbi.nlm.nih.gov/26699811/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:	BIOTIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
823.8 ng/mL REVIEW https://pubmed.ncbi.nlm.nih.gov/26699811/	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	BIOTIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
214.6 ng/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6574044/	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:	BIOTIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN
184 ng/mL REVIEW https://www.future-science.com/doi/pdf/10.4155/ipk-2017-0013	20 mg 1 times / day steady-state, oral dose: 20 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BIOTIN serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
41 ng/mL EXPERIMENT https://www.future-science.com/doi/pdf/10.4155/ipk-2017-0013	5 mg 1 times / day steady-state, oral dose: 5 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BIOTIN serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
91 ng/mL EXPERIMENT https://www.future-science.com/doi/pdf/10.4155/ipk-2017-0013	10 mg 1 times / day steady-state, oral dose: 10 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BIOTIN serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

AUC

Value	Dose	Analyte	Population
1652.4 ng × h/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6574044/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:	BIOTIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN
210 ng × h/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6574044/	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered:	BIOTIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN
2315 ng × h/mL REVIEW https://pubmed.ncbi.nlm.nih.gov/26699811/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:	BIOTIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
4010 ng × h/mL REVIEW https://pubmed.ncbi.nlm.nih.gov/26699811/	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	BIOTIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
605.1 ng × h/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6574044/	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:	BIOTIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
15 h REVIEW https://www.future-science.com/doi/pdf/10.4155/ipk-2017-0013	20 mg 1 times / day steady-state, oral dose: 20 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BIOTIN serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
15 h EXPERIMENT https://www.future-science.com/doi/pdf/10.4155/ipk-2017-0013	5 mg 1 times / day steady-state, oral dose: 5 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BIOTIN serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
15 h EXPERIMENT https://www.future-science.com/doi/pdf/10.4155/ipk-2017-0013	10 mg 1 times / day steady-state, oral dose: 10 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BIOTIN serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

F_unbound

Value	Dose	Co-administered	Analyte	Population
81% REVIEW https://pubmed.ncbi.nlm.nih.gov/26699811/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:		BIOTIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
81% REVIEW https://pubmed.ncbi.nlm.nih.gov/26699811/	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:		BIOTIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
		CYP1B1 51

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
CYP1B1 67	inducer 1573 Sources: https://bioinformatics.charite.de/transformer/index.php?site=fullinfo&cname=000058855, https://pubmed.ncbi.nlm.nih.gov/15333708/	yes

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:15956	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15956
ChemicalBook	CB3271542	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB3271542
MolPort	MolPort-002-507-373	https://www.molport.com/shop/molecule-link/MolPort-002-507-373
Selleck Chemicals	biotin-vitamin-b7	http://www.selleckchem.com/products/biotin-vitamin-b7.html
ZINC	ZINC000035024346	http://zinc15.docking.org/substances/ZINC000035024346
eMolecules	1970569	https://www.emolecules.com/cgi-bin/more?vid=1970569
eMolecules	481810	https://www.emolecules.com/cgi-bin/more?vid=481810

PubMed

Title	Date	PubMed
Prenatal diagnosis and treatment of holocarboxylase synthetase deficiency.	1999 Feb	10215065
Biotin status: which are valid indicators and how do we know?	1999 Feb	10064317
Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization.	1999 May 21	10329687
Molecular mechanism of the intestinal biotin transport process.	1999 Oct	10516089
[Development and identification of T. aestivum-S. cereale-H. villosa double translocation line 1RS.1BL, 6VS.6AL via chromosome C-banding and dual color FISH].	2001	11281000
Amplification methods for the immunolocalization of rare molecules in cells and tissues.	2001	11194866
Enzyme linked immunosorbent assay for determination of amlodipine in plasma.	2001	11170235
Avidin expression during chick chondrocyte and myoblast development in vitro and in vivo: regulation of cell proliferation.	2001 Apr	11282023
Neurotrophic actions of novel compounds designed from cyclopentenone prostaglandins.	2001 Apr	11279261
Expression in Escherichia coli of N- and C-terminally deleted human holocarboxylase synthetase. Influence of the N-terminus on biotinylation and identification of a minimum functional protein.	2001 Apr 13	11124959
The Bacillus subtilis RNase P holoenzyme contains two RNase P RNA and two RNase P protein subunits.	2001 Feb	11233980
Reconstruction of the transected cat spinal cord following NeuroGel implantation: axonal tracing, immunohistochemical and ultrastructural studies.	2001 Feb	11226756
In situ hybridization detection of single-copy human papillomavirus on isolated cells, using a catalyzed signal amplification system: GenPoint.	2001 Feb	11169889
Longitudinal study of anti-Candida albicans mucosal immunity against aspartic proteinases in HIV-infected patients.	2001 Feb 1	11242180
Quantitative analysis of peroxisomal protein import in vitro.	2001 Feb 1	11161709
Use of a biomimetic peptide in the design of a competitive binding assay for biotin and biotin analogues.	2001 Feb 1	11161298
Green fluorescent protein mutant as label in homogeneous assays for biomolecules.	2001 Feb 1	11161294
Stimulation of intercellular communication of poor-communicating cells by gap-junction-competent cells enhances the HSV-TK/GCV bystander effect in vitro.	2001 Feb 15	11251978
Effects of serotonin depletion on local interneurons in the developing olfactory pathway of lobsters.	2001 Feb 15	11169505
Mutational analysis of protein substrate presentation in the post-translational attachment of biotin to biotin domains.	2001 Feb 2	11042165
Combined laser tweezers and dielectric field cage for the analysis of receptor-ligand interactions on single cells.	2001 Jan	11288894
Profiling the specific reactivity of the proteome with non-directed activity-based probes.	2001 Jan	11182321
Cortical innervation of the facial nucleus in the non-human primate: a new interpretation of the effects of stroke and related subtotal brain trauma on the muscles of facial expression.	2001 Jan	11133797
Sensitive nonradioactive detection of mRNA in tissue sections: novel application of the whole-mount in situ hybridization protocol.	2001 Jan	11118473
Liposomes labeled with biotin and horseradish peroxidase: a probe for the enhanced amplification of antigen--antibody or oligonucleotide--DNA sensing processes by the precipitation of an insoluble product on electrodes.	2001 Jan 1	11195517
A novel anionic modification of N-glycans on mammalian endothelial cells is recognized by activated neutrophils and modulates acute inflammatory responses.	2001 Jan 1	11123346
Trigemino-reticulo-facial and trigemino-reticulo-hypoglossal pathways in the rat.	2001 Jan 1	11086291
Use of two anterograde axon tracers to label distinct cortical neuronal populations located in close proximity.	2001 Jan 15	11164243
Course of motor and associative pallidothalamic projections in monkeys.	2001 Jan 15	11116233
Vestibular efferent neurons project to the flocculus.	2001 Jan 19	11166721
Y retinal terminals contact interneurons in the cat dorsal lateral geniculate nucleus.	2001 Jan 29	11135247
Thermodynamic and kinetic effects of N3'-->P5' phosphoramidate modification on pyrimidine motif triplex DNA formation.	2001 Jan 30	11170429
Avidin-biotin-immobilized liposome column for chromatographic fluorescence on-line analysis of solute-membrane interactions.	2001 Jan 5	11204223
Confocal microscopic study of glial-vascular relationships in the retinas of pigmented rats.	2001 Jan 8	11116218
Solid-phase synthesis of a radiolabeled, biotinylated, and farnesylated Ca(1)a(2)X peptide substrate for Ras- and a-mating factor converting enzyme.	2001 Jan-Feb	11170363
Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95.	2001 Jun 1	11279080
PCR-ELISAs for the detection of Campylobacter jejuni and Campylobacter coli in poultry samples.	2001 Mar	11252796
Synthesis and application of circularizable ligation probes.	2001 Mar	11252794
Molecular characterization of the 5' regulatory region of rat sodium-dependent multivitamin transporter gene.	2001 Mar	11171574
Investigating the surface expression of the renal type IIa Na+/Pi-cotransporter in Xenopus laevis oocytes.	2001 Mar 1	11284206
Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors.	2001 Mar 1	11240015
Biotin induces tetramerization of a recombinant monomeric avidin. A model for protein-protein interactions.	2001 Mar 16	11076945
Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP.	2001 Mar 5	11245926

Patents

Sample Use Guides

In Vivo Use Guide

Recommended daily dosage is 10 ml (in a form of infuvite adult) or 1 tablet a day in a form of Biotin dietary supplement (the dosage may vary).

Route of Administration: Other

In Vitro Use Guide

Human T lymphoma Jurkat cells and monocytic myeloid U937 cells were incubated with different concentrations of biotin (nM): 0.025, 0.25 and 10, representing plasma levels in biotin-deﬁcient, biotin-sufﬁcient and biotin-supplemented adults. When taken together with folate, biotin synergizes in the repression of pro-inﬂammatory cytokines and long-terminal repeats (LTRs), mediated by interactions between HLCS and other chromatin proteins.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:46:56 GMT 2023` Edited by `admin` on `Sat Dec 16 18:46:56 GMT 2023`
Record UNII	N7LEJ9M9EU
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BIOTIN SODIUM

Common Name

English

1H-THIENO(3,4-D)IMIDAZOLE-4-PENTANOIC ACID, HEXAHYDRO-2-OXO-, MONOSODIUM SALT, (3AS,4S,6AR)-

Common Name

English

1H-THIENO(3,4-D)IMIDAZOLE-4-PENTANOIC ACID, HEXAHYDRO-2-OXO-, MONOSODIUM SALT, (3AS-(3A.ALPHA.,4.BETA.,6A.ALPHA.))-

Common Name

English

1H-THIENO(3,4-D)IMIDAZOLE-4-PENTANOIC ACID, HEXAHYDRO-2-OXO-, SODIUM SALT (1:1), (3AS,4S,6AR)-

Common Name

English

BIOTIN SODIUM SALT

Common Name

English

Code System Code Type Description

PUBCHEM

24892859

Created by admin on Sat Dec 16 18:46:56 GMT 2023 , Edited by admin on Sat Dec 16 18:46:56 GMT 2023

PRIMARY

CAS

56085-82-6

Created by admin on Sat Dec 16 18:46:56 GMT 2023 , Edited by admin on Sat Dec 16 18:46:56 GMT 2023

PRIMARY

SMS_ID

100000129407

Created by admin on Sat Dec 16 18:46:56 GMT 2023 , Edited by admin on Sat Dec 16 18:46:56 GMT 2023

PRIMARY

FDA UNII

N7LEJ9M9EU

Created by admin on Sat Dec 16 18:46:56 GMT 2023 , Edited by admin on Sat Dec 16 18:46:56 GMT 2023

PRIMARY

Related Record Type Details


					6SO6U10H04

BIOTIN

PARENT -> SALT/SOLVATE

Amount:

Related Record Type Details


					6SO6U10H04

BIOTIN

ACTIVE MOIETY

Amount:

Details

SMILES

InChI

DescriptionSources: www.ncbi.nlm.nih.gov/pubmed/18356320Curator's Comment: description was created based on several sources, including www.ncbi.nlm.nih.gov/pubmed/17182796, www.ncbi.nlm.nih.gov/pubmed/19056639

CNS Activity

Approval Year

Conditions

Approved Use

Launch Date

Approved Use

Cmax

AUC

T1/2

Funbound

Overview

OverviewOther

Drug as perpetrator​

Sourcing

PubMed

Patents

Sample Use Guides

Description
Sources: www.ncbi.nlm.nih.gov/pubmed/18356320
Curator's Comment: description was created based on several sources, including www.ncbi.nlm.nih.gov/pubmed/17182796, www.ncbi.nlm.nih.gov/pubmed/19056639

C_max

T_1/2

F_unbound

Drug as perpetrator