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Showing 21 - 22 of 22 results

AZELASTINE HYDROCHLORIDE, (S)-

MORE DETAILS

  QGN83XMX5P

Status:
Possibly Marketed Outside US
Source:
ASTELIN by Muro Pharmaceutical
Source URL:
http://adisinsight.springer.com/drugs/800014112
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Histamine H1 receptor
315
Conditions:
Allergic rhinitis
100
Azelastine (brand names AZEP, ASTEPRO, ASTELIN etc.) a phthalazine derivative, is an antihistamine and mast cell stabilizer available as a nasal spray for hay fever and as eye drops for allergic conjunctivitis. Azelastine is a potent antiallergic compound with histamine H1-receptor antagonist activity and a rapid onset and long duration of action. The major metabolite, desmethylazelastine, also exhibits H1- receptor antagonist activity. AZEP Nasal Spray is administered as a racemic mixture. The racemate, R- and S- enantiomers were equally potent at inhibiting eyelid histamine-induced oedema in rats, however the R-enantiomer was 2-fold less active at inhibiting eyeball histamine-induced oedema.

AZELASTINE HYDROCHLORIDE, (R)-

MORE DETAILS

  A33K416J2W

Status:
Possibly Marketed Outside US
Source:
ASTELIN by Muro Pharmaceutical
Source URL:
http://adisinsight.springer.com/drugs/800014112
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Histamine H1 receptor
315
Conditions:
Allergic rhinitis
100
Azelastine (brand names AZEP, ASTEPRO, ASTELIN etc.) a phthalazine derivative, is an antihistamine and mast cell stabilizer available as a nasal spray for hay fever and as eye drops for allergic conjunctivitis. Azelastine is a potent antiallergic compound with histamine H1-receptor antagonist activity and a rapid onset and long duration of action. The major metabolite, desmethylazelastine, also exhibits H1- receptor antagonist activity. AZEP Nasal Spray is administered as a racemic mixture. The racemate, R- and S- enantiomers were equally potent at inhibiting eyelid histamine-induced oedema in rats, however the R-enantiomer was 2-fold less active at inhibiting eyeball histamine-induced oedema.
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