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Trimethylcolchicinic acid (also known as deacetyl colchicine) was used for patients with advanced malignancies. However, these studies were discontinued. Expeiments on rat were shown, that trimethylcolchicinic acid was able to improve normal liver histology, ultrastructure, collagen content and biochemical markers of liver damage in spite of that trimethylcolchicinic acid, didn't bind tubulin.