U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 241 - 250 of 7691 results

Status:
Investigational
Source:
NCT02815488: Phase 1/Phase 2 Interventional Terminated Chronic Obstructive Pulmonary Disease
(2016)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:Sunvozertinib [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
NCT01125644: Phase 3 Interventional Unknown status Cryptococcosis or Aspergillosis Infections
(2010)
Source URL:

Class (Stereo):
CHEMICAL (EPIMERIC)

SPK-843 is a water-soluble partricin derivative patented by SPA Societa Prodotti Antibiotici S.p.A. and developed by Aparts and Kaken for the potential treatment of systemic fungal infections. In preclinical models, SPK-843 shows in vitro inhibitory activity comparable to or better than that of Amphotericin B against Candida spp., Cryptococcus neoformans, and Aspergillus spp. SPK-843 exhibits dose-dependent efficacy on murine pulmonary aspergillosis models. SPK-843 doses of higher than 1.0 mg/kg of body weight exhibit no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone) and liposomal amphotericin B.
Status:
Investigational
Source:
NCT03092934: Phase 1/Phase 2 Interventional Completed Neoplasms
(2017)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
NCT01211249: Phase 2 Interventional Completed Rheumatoid Arthritis
(2010)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
NCT04270591: Phase 1/Phase 2 Interventional Recruiting C-Met Exon 14 Mutation
(2019)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:tizaterkib [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
NCT04541082: Phase 1 Interventional Recruiting Central Nervous System Neoplasms
(2020)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:ruclosporin [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Ruclosporin is a calcineurin inhibitor that was developed as an immunosuppressant. Information about the further development of this compound is not available.
Status:
Investigational
Source:
NCT03903549: Phase 1 Interventional Completed Parkinson Disease
(2022)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)