Gumarontinib

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H17N9O2S
Molecular Weight	459.484
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C=C(C=N1)C2=CN3C(C=C2)=NC=C3S(=O)(=O)N4N=CC5=NC=C(C=C45)C6=CN(C)N=C6

InChI

InChIKey=RYBLECYFLJXEJX-UHFFFAOYSA-N

InChI=1S/C21H17N9O2S/c1-27-11-16(7-24-27)14-3-4-20-23-10-21(29(20)13-14)33(31,32)30-19-5-15(6-22-18(19)9-26-30)17-8-25-28(2)12-17/h3-13H,1-2H3

HIDE SMILES / InChI

Molecular Formula	C21H17N9O2S
Molecular Weight	459.484
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

C_max

Value	Dose	Analyte	Population
868.7 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36925997/	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	GLUMETINIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
1729.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36925997/	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	GLUMETINIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: HIGH-FAT
1748.9 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36925997/	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	GLUMETINIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: LOW-FAT

AUC

Value	Dose	Analyte	Population
27727 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36925997/	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	GLUMETINIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
65089.9 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36925997/	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	GLUMETINIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: HIGH-FAT
60508 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36925997/	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	GLUMETINIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: LOW-FAT

T_1/2

Value	Dose	Analyte	Population
26.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36925997/	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	GLUMETINIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
24.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36925997/	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	GLUMETINIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: HIGH-FAT
25.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36925997/	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	GLUMETINIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: LOW-FAT

Substance Class	Chemical Created by `admin` on `Wed Apr 02 00:26:45 GMT 2025` Edited by `admin` on `Wed Apr 02 00:26:45 GMT 2025`
Record UNII	7JTT036WGX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Gumarontinib

Official Name

English

SC-C244

Preferred Name

English

6-(1-methyl-1H-pyrazol-4-yl)-1-[6-(1-methyl-1Hpyrazol-4-yl)imidazo[1,2-a]pyridine-3-sulfonyl]-1Hpyrazolo[4,3-b]pyridine

Systematic Name

English

gumarontinib [INN]

Common Name

English

GLUMETINIB

Common Name

English

Glumetinib [WHO-DD]

Common Name

English

SCC244

Code

English

1H-Pyrazolo[4,3-b]pyridine, 6-(1-methyl-1H-pyrazol-4-yl)-1-[[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]sulfonyl]-

Systematic Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

858221