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Approval Year

Substance Class
Concept
Record UNII
1WX8O5XV4R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AK-01
Code English
1-((3-CHLORO-2-FLUOROPHENYL)METHYL)-4-((3-FLUORO-6-((5-METHYL-1H-PYRAZOL-3-YL)AMINO)-2-PYRIDINYL)METHYL)-2-METHYL-, (2R,4R)-,4-PIPERIDINECARBOXYLIC ACID
Systematic Name English
LY3295668
Code English
AURORA A KINASE INHIBITOR LY3295668
Common Name English
4-PIPERIDINECARBOXYLIC ACID, 1-((3-CHLORO-2-FLUOROPHENYL)METHYL)-4-((3-FLUORO-6-((5-METHYL-1H-PYRAZOL-3-YL)AMINO)-2-PYRIDINYL)METHYL)-2-METHYL-, (2R,4R)-
Systematic Name English
LY-3295668
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 724119
Created by admin on Fri Jun 25 23:17:43 UTC 2021 , Edited by admin on Fri Jun 25 23:17:43 UTC 2021
Code System Code Type Description
CAS
1919888-06-4
Created by admin on Fri Jun 25 23:17:43 UTC 2021 , Edited by admin on Fri Jun 25 23:17:43 UTC 2021
PRIMARY
NCI_THESAURUS
C148501
Created by admin on Fri Jun 25 23:17:43 UTC 2021 , Edited by admin on Fri Jun 25 23:17:43 UTC 2021
PRIMARY
PUBCHEM
121333423
Created by admin on Fri Jun 25 23:17:43 UTC 2021 , Edited by admin on Fri Jun 25 23:17:43 UTC 2021
PRIMARY
FDA UNII
1WX8O5XV4R
Created by admin on Fri Jun 25 23:17:43 UTC 2021 , Edited by admin on Fri Jun 25 23:17:43 UTC 2021
PRIMARY
This is a non-substance concept
Related Record Type Details
TARGET -> INHIBITOR
96 out of 348 cell lines displayed significant sensitivity (absolute IC50 < 0.4 ?M) to LY3295668. The majority of the small cell lung cancer and neuroblastoma cell lines are sensitive to LY3295668 treatment. Significant association between Rb1 mutations and sensitivity to LY3295668 was identified.
IC50
TARGET->WEAK INHIBITOR
IC50
Related Record Type Details
ACTIVE MOIETY
This is a non-substance concept