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Restrict the search for
m nalidixic acid
to a specific field?
Class (Stereo):
CHEMICAL (RACEMIC)
Quincarbate is a quinoline derivative patented by N. V. Philips' Gloeilampenfabrieken as diuretic. At 12.5 mg/kg orally in rats Quincarbate increased urine excretion by 130%.
Class (Stereo):
CHEMICAL (ACHIRAL)
Bufrolin is xanthine derivative and mast cell stabilizer with antiallergic activity. In recent studies, Bufrolin was found to be high potency agonists of human GPR35.
Status:
Investigational
Source:
INN:fandosentan [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Fandosentan (CI 1034 or PD 180988) is an endothelin A receptor antagonist. It inhibits pulmonary vasoconstriction. Fandosentan was being developed for the treatment of chronic obstructive pulmonary disease and pulmonary hypertension.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Tiplasinin (PAI-039) is an orally efficacious and selective plasminogen activator inhibitor-1 (PAI-1) inhibitor. Tiplasinin bound specifically to the active conformation of PAI-1 and exhibited reversible inactivation of PAI-1 in vitro. Tiplaxtinin exhibited in vivo oral efficacy in two different models of acute arterial thrombosis. The remarkable preclinical safety and metabolic stability profiles of tiplaxtinin led to advancing the compound to Phase-I clinical trial for Thrombosis, which was later discontinued.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Clanobutin is a choleretic drug. It increases the secretion of bile by hepatocytes. Clanobutin sodium has been introduced as a choleretic and digestant agent for animals. It has been used in all domestic animals in which enhancement of digestion and all associated secretory processes are indicated. Clanobutin was reported to induce a demonstrable increase in the secretory activity of the exocrine digestive glands and in the excretion of the bile.
Status:
Investigational
Source:
NCT00479427: Phase 2 Interventional Completed Osteoarthritis
(2007)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
GW842166 is a pyrimidine cannabinoid 2 (CB2) receptor agonist that was being developed by GlaxoSmithKline for the treatment of inflammatory pain. It has potent analgesic, anti-inflammatory and anti-hyperalgesic actions in animal models, but without cannabis-like behavioural effects due to its extremely low affinity for the CB1 receptor. GW842166 shows similar potency and efficacy for rat and human recombinant CB2 receptors with EC50 of 91 nM and 63nM, respectively. GW842166 is in Phase 2 trial.
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
Lemildipine is a 1,4-dihydropyridine calcium channel blocker which is under phase III development by Banyu (Merck and Co), in Japan, for its potential to treat hypertension and cerebrovascular ischemia. In one study, involving five patients with essential hypertension accompanied by cerebrovascular disorder, lemildipine, administered orally at doses of 5 to 20 mg/day, significantly lowered blood pressure and increased cerebral blood flow. Another study in 31 patients with essential hypertension demonstrated that lemildipine has significant pressure lowering effects without affecting serum lipids. Worldwide rights to market the drug have been assigned to Kowa in Japan.
Status:
Investigational
Source:
INN:fepentolic acid [INN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
FEPENTOLIC ACID is a choleretic agent.
Class (Stereo):
CHEMICAL (MIXED)
Etanterol (VAL 481), a phenethanolamine derivative, is a β2 adrenoceptor agonist that was undergoing phase II trials in Italy as a bronchodilator with Valeas.
Status:
Investigational
Source:
JAN:ISONIAZID CALCIUM PYRUVINATE [JAN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
