FOMIDACILLIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H28N6O10S
Molecular Weight	592.578
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN1CCN(C(=O)N[C@@H](C(=O)N[C@@]2(NC=O)[C@H]3SC(C)(C)[C@@H](N3C2=O)C(O)=O)C4=CC=C(O)C(O)=C4)C(=O)C1=O

InChI

InChIKey=BLHZPPIRNRDRSC-HSDAMQNGSA-N

InChI=1S/C24H28N6O10S/c1-4-28-7-8-29(18(36)17(28)35)22(40)26-14(11-5-6-12(32)13(33)9-11)16(34)27-24(25-10-31)20(39)30-15(19(37)38)23(2,3)41-21(24)30/h5-6,9-10,14-15,21,32-33H,4,7-8H2,1-3H3,(H,25,31)(H,26,40)(H,27,34)(H,37,38)/t14-,15+,21-,24-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C24H28N6O10S
Molecular Weight	592.578
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3087281 | https://www.ncbi.nlm.nih.gov/pubmed/3755314

Fomidacillin (also known as BRL 36650) is a type of penicillin with antibacterial activity. Studies on volunteers have shown that the drug possessed the bactericidal activity and could be a candidate for the treatment of gram-negative bacillary infections. However, information about the further development of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
In-vitro activity of BRL-36650, a novel beta-lactamase-stable penicillin, against multiply resistant gram-negative organisms.	1986-09	3095299
Antimicrobial activity and beta-lactamase stability of foramidocillin.	1986-05	3488017
In vitro activity of BRL 36650, a new penicillin.	1986-02	3087281
In vitro antibacterial properties of BRL 36650, a novel 6 alpha-substituted penicillin.	1984-11	6440479

Sample Use Guides

In Vivo Use Guide

Ten healthy volunteers received 1 g of BRL-36650 (FOMIDACILLIN) given by intravenous infusion over 15 min.

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:08:27 GMT 2025` Edited by `admin` on `Mon Mar 31 18:08:27 GMT 2025`
Record UNII	9H7VJE7A17
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FOMIDACILLIN

Official Name

English

fomidacillin [INN]

Preferred Name

English

(2S,5R,6R)-6-((R)-2-(3,4-DIHYDROXYPHENYL)-2-(4-ETHYL-2,3-DIOXO-1-PIPERAZINECARBOXAMIDO)ACETAMIDO)-6-FORMAMIDO-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1500