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Restrict the search for
methyl salicylate
to a specific field?
Status:
Investigational
Source:
NCT01905540: Phase 1 Interventional Completed Healthy
(2013)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Deferitazole is an iron chelator, developed by the FerroKin BioSciences (later acquired by Shire, and then by Takeda). Deferitazole is a member of the desazadesferrithiocin class of siderophore-related tridentate chelators. It binds Fe(III) with very high affinity and selectivity over Fe(II) and other biologically important metals. Deferitazole was investigated in phase 2 clinical trials in patients with iron overload due to repeated red blood cell transfusion and beta-thalassemia, however, the development of the drug was discontinued. In preclinical models, deferitazole demonstrated efficacy for the treatment and prevention of malaria.
Status:
Investigational
Class (Stereo):
CHEMICAL (RACEMIC)
Losindole (BI-27,062) is an antidepressant with a tricyclic structure. It was never marketed.
Status:
Investigational
Source:
INN:clofenetamine [INN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Clofenetamine is a haloxanthine antihistamine compound discovered by Searle & Co in the 1940s.
Class (Stereo):
CHEMICAL (RACEMIC)
Status:
Investigational
Source:
NCT02714543: Phase 3 Interventional Completed Oral SubMucous Fibrosis
(2013)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT00458016: Phase 2 Interventional Completed Type 2 Diabetes Mellitus
(2007)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
MB-07803 (VK-0612) is a potent inhibitor of fructose-1,6-bisphosphatase (FBPase). Inhibition of FBPase is an effective mechanism for lowering fasting and postprandial hyperglycemia in patients with poorly-controlled Type 2 diabetes. Viking Therapeutics is developing MB-07803 for the treatment of type 2 diabetes.
Class (Stereo):
CHEMICAL (ACHIRAL)
Quazolast is an orally active mast cell stabilising agent which was in development with Rhône-Poulenc Rorer. In preclinical trials Quazolast was evaluated for efficacy against acid independent (alcohol, HCl), or dependent (aspirin, indomethacin) gastric damage in rats. Quazolasts gastroprotective profile was compared to that of ranitidine. Quazolast, in direct contrast to ranitidine, protected the rat gastric mucosa from acid-independent, but not acid-dependent gastric damage. Quazolast lacked antisecretory activity in rats; however, it did heal acetic acid induced gastric ulcers in this species. In clinical trials Quazolast was superior to placebo in protecting against nasal congestion and nasal itchiness after ragweed nasal challenge.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Nufenoxole is an orally active antidiarrhoeal agent which binds to opioid receptors in the brain and myenteric plexus of the intestine. Nufenoxole is well absorbed in rat, monkey and human after oral administration. Systemic availability of nufenoxole was 85% in monkey and 102% in man. The elimination rate was much faster in rat (t1/2 of 1.8 h) and monkey (t1/2 of 4.9 h) compared with human (t1/2 of 35.8 h). Nufenoxole possesses potent antisecretory properties, which are mediated via opioid receptors and may contribute to its antidiarrhoeal action in man.
Status:
Investigational
Source:
NCT04182126: Not Applicable Interventional Completed LLIN, PBO LLIN, IRS, Larviciding
(2019)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT01092689: Phase 1 Interventional Withdrawn Pancreas Cancer
(2012)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mutagenic and carcinogenic heterocyclic amine formed during ordinary cooking, and is subsequently metabolically activated by cytochrome P4501A2 (CYP1A2) and N-acetyltransferase 2 (NAT2). PhIP has been used in trials studying the basic science of Pancreas Cancer.
