U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C24H37N4O7PS
Molecular Weight 556.612
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MB-07803

SMILES

CCOC(=O)C(C)(C)NP(=O)(NC(C)(C)C(=O)OCC)C1=CC=C(O1)C2=C(SC(N)=N2)C(=O)C(C)(C)C

InChI

InChIKey=CTKZZUXRWBCFEI-UHFFFAOYSA-N
InChI=1S/C24H37N4O7PS/c1-10-33-19(30)23(6,7)27-36(32,28-24(8,9)20(31)34-11-2)15-13-12-14(35-15)16-17(37-21(25)26-16)18(29)22(3,4)5/h12-13H,10-11H2,1-9H3,(H2,25,26)(H2,27,28,32)

HIDE SMILES / InChI
Molecular Formula C24H37N4O7PS
Molecular Weight 556.612
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

MB-07803 (VK-0612) is a potent inhibitor of fructose-1,6-bisphosphatase (FBPase). Inhibition of FBPase is an effective mechanism for lowering fasting and postprandial hyperglycemia in patients with poorly-controlled Type 2 diabetes. Viking Therapeutics is developing MB-07803 for the treatment of type 2 diabetes.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed

Sample Use Guides

In Vivo Use Guide
he Phase 2a proof‐of‐concept trial was conducted in patients with moderate to severe type 2 diabetes. In this trial, patients received either placebo or MB-07803 (VK-0612) (10, 50, 100 or 200 mg capsule) once-daily for 28 days.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:37:02 GMT 2023
Edited
by admin
on Fri Dec 15 17:37:02 GMT 2023
Record UNII
GG81XF45C2
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MB-07803
Common Name English
MB07803
Common Name English
ALANINE, N,N'-((5-(2-AMINO-5-(2,2-DIMETHYL-1-OXOPROPYL)-4-THIAZOLYL)-2-FURANYL)PHOSPHINYLIDENE)BIS(2-METHYL-, DIETHYL ESTER
Common Name English
ALANINE, N,N'-((5-(2-AMINO-5-(2,2-DIMETHYL-1-OXOPROPYL)-4-THIAZOLYL)-2-FURANYL)PHOSPHINYLIDENE)BIS(2-METHYL-, 1,1''-DIETHYL ESTER
Common Name English
MB 07803
Code English
Code System Code Type Description
FDA UNII
GG81XF45C2
Created by admin on Fri Dec 15 17:37:02 GMT 2023 , Edited by admin on Fri Dec 15 17:37:02 GMT 2023
PRIMARY
DRUG BANK
DB05053
Created by admin on Fri Dec 15 17:37:02 GMT 2023 , Edited by admin on Fri Dec 15 17:37:02 GMT 2023
PRIMARY
EPA CompTox
DTXSID90236932
Created by admin on Fri Dec 15 17:37:02 GMT 2023 , Edited by admin on Fri Dec 15 17:37:02 GMT 2023
PRIMARY
CAS
882757-24-6
Created by admin on Fri Dec 15 17:37:02 GMT 2023 , Edited by admin on Fri Dec 15 17:37:02 GMT 2023
PRIMARY
PUBCHEM
24770445
Created by admin on Fri Dec 15 17:37:02 GMT 2023 , Edited by admin on Fri Dec 15 17:37:02 GMT 2023
PRIMARY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966