U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 211 - 220 of 3518 results

Status:
Investigational
Source:
NCT00344812: Phase 2 Interventional Completed Opioid Dependence
(1996)
Source URL:

Class (Stereo):
CHEMICAL (MIXED)

Dimepheptanol is one of the phenylpiperidine series, an opioid receptor agonist, which is active as an opioid analgesic. It is also elaborated in a number of close analogues, derivatives or diastereoisomers with similar properties. Dimepheptanol is a synthetic narcotic analgesic that has no accepted medical use in the United States.
Status:
Investigational
Source:
INN:laurolinium acetate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

LAUROLINIUM, a quaternary ammonium compound, is a cationic antimicrobial agent. It has a broad spectrum of activity against Gram‐positive and Gram‐negative bacteria, fungi, and protozoan Trichomonas vaginalis. It is suitable for use in the treatment of local infections, for the sterilization of skin areas and for general antiseptic purposes.
Status:
Investigational
Source:
NCT04374032: Phase 2/Phase 3 Interventional Completed COVID-19 Infection
(2020)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Metenkephalin (Met-enkephalin) is an endogenous opioid peptide that acts as an agonist at μ-opioid receptors (μORs) and δ-opioid receptors (δORs). Met-enkephalin exhibits neuromodulatory, antinociceptive/analgesic, antidepressant, and gastrointestinal motility modulating activities. Like other endogenous opioids, met-enkephalin modulates expression of opioid receptors and plays a role in reward/reinforcement signaling. Met-enkephalin is also involved in exercise-induced reversal of neuropathic pain and in animals undergoing the forced swim test, decreases immobility time. Met-enkephalin inhibits gastrointestinal muscle contractility, inhibiting motility and gastric emptying. Additionally, analogs of this peptide display anticancer and antiepileptic/anticonvulsant activities.
Status:
Investigational
Source:
INN:stenbolone
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Stenbolone is an anabolic–androgenic steroid of the dihydrotestosterone group patented by Schering AG but never marketed. Ester prodrug of stenbolone is used as an anabolic–androgenic steroid for depot intramuscular injection under the brand names Anatrofin and Stenobolone.
Status:
Investigational
Source:
USAN:Asperlin
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Asperlin (also known as U-13,933), a fungal natural product that was isolated from marine-derived fungus Aspergillus sp. SF-5044 and exhibits antifungal and anti-inflammatory properties in vitro. Experiments in vivo have shown that this compound can prevent atherosclerosis through suppressing inflammation rather than ameliorating dyslipidemia. In addition, asperlin can be developed as a potential anti-cancer therapeutics. It shows anti-cancer properties through ROS generation and ATM pathway in human cervical carcinoma cells.
Status:
Investigational
Source:
USAN:Acetyltannic Acid
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Acetyltannic acid is an astringent (intestinal) for foals, calves, dogs. It is used for treatment of diarrhoea.
Status:
Investigational
Source:
INN:rifamide
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Rifamides (NSC-143418) are drugs used in the treatment of tuberculosis. They also have immunosuppressive activity, the exact mechanism of which is still unknown, although the ability of rifamides to inhibit tumor necrosis factor (TNF)-induced NF-kB activation may be associated with it. A variety of rifamide analogues exist, such as rifamycin B, rifapentine, rifamycin SV, rifabutin and rifampicin.
Status:
Investigational
Source:
INN:tocofenoxate [INN]
Source URL:

Class (Stereo):
CHEMICAL (MIXED)

Tocofenoxate is a semisynthetic tocopherol derivative. Vitamin E supplement.
Status:
Investigational
Source:
INN:estrofurate
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Estrofurate (AY-11483) is an impeded estrogen. it prevents ovulation and implantation.
Status:
Investigational
Source:
INN:acetorphine
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Acetorphine is a synthetic narcotic analgesic. Acetorphine was reported to have uses in veterinary medicine with pronounced advantages in the immobilization of the giraffe in which toxic effects were reduced as compared to the effects of etorphine. In July 1966, the Director-General of the World Health Organization informed the Secretary-General that WHO had arrived at the conclusion that etorphine and acetorphine should be included in Schedule I of the Convention, since they could give rise to similar abuse, and produce similar ill effects as the substances already listed therein. Acetorphine is a Schedule I controlled substance in the United States.