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Restrict the search for
m didanosine
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
IMB-10 stabilizes binding of alpha(M)beta(2) to its endogenous ligands proMMP-9 and fibrinogen. It inhibited alpha(M)beta(2)-dependent migration in vitro and inflammation-induced neutrophil emigration in vivo. IMB-10 therapy inhibited the growth of both leukemia and lymphoma xenografts and significantly prolonged the survival of the mice with lymphoma. IMB-10 has potential as a therapy for leukocytic malignancies, particularly for lymphomas.
