Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H15NOS2 |
| Molecular Weight | 337.459 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC=CC=C1N2C(=S)S\C(=C/C=C/C3=CC=CC=C3)C2=O
InChI
InChIKey=UYZLENPCNZVWQZ-DNZSEPECSA-N
InChI=1S/C19H15NOS2/c1-14-8-5-6-12-16(14)20-18(21)17(23-19(20)22)13-7-11-15-9-3-2-4-10-15/h2-13H,1H3/b11-7+,17-13-
| Molecular Formula | C19H15NOS2 |
| Molecular Weight | 337.459 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Optical Activity | NONE |
IMB-10 stabilizes binding of alpha(M)beta(2) to its endogenous ligands proMMP-9 and fibrinogen. It inhibited alpha(M)beta(2)-dependent migration in vitro and inflammation-induced neutrophil emigration in vivo. IMB-10 therapy inhibited the growth of both leukemia and lymphoma xenografts and significantly prolonged the survival of the mice with lymphoma. IMB-10 has potential as a therapy for leukocytic malignancies, particularly for lymphomas.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Stabilization of the activated alphaMbeta2 integrin by a small molecule inhibits leukocyte migration and recruitment. | 2006 Mar 7 |
|
| A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18. | 2007 Apr |
|
| Identification of novel agonists of the integrin CD11b/CD18. | 2009 Dec 15 |
|
| Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. | 2011 Sep 6 |
|
| Small molecule agonist of very late antigen-4 (VLA-4) integrin induces progenitor cell adhesion. | 2013 Jul 5 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:30:25 GMT 2023
by
admin
on
Sat Dec 16 08:30:25 GMT 2023
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| Record UNII |
9DDO6X234Z
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Code System | Code | Type | Description | ||
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307525-40-2
Created by
admin on Sat Dec 16 08:30:25 GMT 2023 , Edited by admin on Sat Dec 16 08:30:25 GMT 2023
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DTXSID40184777
Created by
admin on Sat Dec 16 08:30:25 GMT 2023 , Edited by admin on Sat Dec 16 08:30:25 GMT 2023
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1555648
Created by
admin on Sat Dec 16 08:30:25 GMT 2023 , Edited by admin on Sat Dec 16 08:30:25 GMT 2023
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9DDO6X234Z
Created by
admin on Sat Dec 16 08:30:25 GMT 2023 , Edited by admin on Sat Dec 16 08:30:25 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |
