Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H15NOS2 |
| Molecular Weight | 337.459 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC=CC=C1N2C(=S)S\C(=C/C=C/C3=CC=CC=C3)C2=O
InChI
InChIKey=UYZLENPCNZVWQZ-DNZSEPECSA-N
InChI=1S/C19H15NOS2/c1-14-8-5-6-12-16(14)20-18(21)17(23-19(20)22)13-7-11-15-9-3-2-4-10-15/h2-13H,1H3/b11-7+,17-13-
IMB-10 stabilizes binding of alpha(M)beta(2) to its endogenous ligands proMMP-9 and fibrinogen. It inhibited alpha(M)beta(2)-dependent migration in vitro and inflammation-induced neutrophil emigration in vivo. IMB-10 therapy inhibited the growth of both leukemia and lymphoma xenografts and significantly prolonged the survival of the mice with lymphoma. IMB-10 has potential as a therapy for leukocytic malignancies, particularly for lymphomas.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Can Integrin Agonists Have Cards to Play against Cancer? A Literature Survey of Small Molecules Integrin Activators. | 2017-07-05 |
|
| Small molecule agonist of very late antigen-4 (VLA-4) integrin induces progenitor cell adhesion. | 2013-07-05 |
|
| Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. | 2011-09-06 |
|
| Identification of novel agonists of the integrin CD11b/CD18. | 2009-12-15 |
|
| AlphaMbeta2 integrin modulator exerts antitumor activity in vivo. | 2008-01-30 |
|
| A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18. | 2007-04 |
|
| Stabilization of the activated alphaMbeta2 integrin by a small molecule inhibits leukocyte migration and recruitment. | 2006-03-07 |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Preferred Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
307525-40-2
Created by
admin on Mon Mar 31 22:07:33 GMT 2025 , Edited by admin on Mon Mar 31 22:07:33 GMT 2025
|
PRIMARY | |||
|
DTXSID40184777
Created by
admin on Mon Mar 31 22:07:33 GMT 2025 , Edited by admin on Mon Mar 31 22:07:33 GMT 2025
|
PRIMARY | |||
|
1555648
Created by
admin on Mon Mar 31 22:07:33 GMT 2025 , Edited by admin on Mon Mar 31 22:07:33 GMT 2025
|
PRIMARY | |||
|
9DDO6X234Z
Created by
admin on Mon Mar 31 22:07:33 GMT 2025 , Edited by admin on Mon Mar 31 22:07:33 GMT 2025
|
PRIMARY |
ACTIVE MOIETY
