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Restrict the search for
adenosine
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Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
5-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues. The major source of MTA in cells is formed from S-adenosylmethionine during the synthesis of the polyamines spermine and spermidine. In most cells MTA does not accumulate is significant amounts and is rapidly metabolized by 5-methythioadenosine phosphorylase (MTAP) to yield adenine (Ade) and 5-methylthioribose-1-phosphate (MTR1P). The removal of accumulating MTA by MTAP is necessary for the cell to carry out polyamine metabolism, since MTA is a strong inhibitor of spermine synthase. Intracellular fluctuations in MTA levels could participate in the regulation of the liver proliferative response, and administration of MTA have hepatorptective effect in a model of CCl4-induced chronic liver damage.
