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Restrict the search for
adenosine
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Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
5'-Methylthioadenosine, also known as methylthioadenosine or MTA, is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues. MTA is produced from S-adenosylmethionine mainly through the polyamine biosynthetic pathway, where it behaves as a powerful inhibitory product. This compound is metabolized solely by 5'-methylthioadenosine phosphorylase (MTAP), to yield 5-methylthioribose-1-phosphate and adenine, a crucial step in the methionine and purine salvage pathways, respectively. MTA has been shown to influence numerous critical responses of the cell including regulation of gene expression, proliferation, differentiation and apoptosis. Also was shown that MTA inhibits melanoma cell proliferation and in vivo tumor growth particularly in BRAF mutant melanoma cells. These data reveal a naturally occurring drug potentially useful for melanoma treatment.
