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Restrict the search for
adenosine
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
SCH-442416 is a selective antagonist of the adenosine A2a receptor with a Ki of 0.48 nM. It was first designed and developed as an [11C] radioisotope for PET imaging and has seen some use as an investigational and diagnostic tool, including one human study (see: SCH-442416 C-11). The non-radiolabeled compound has garnered less interest. SCH-442416 has been investigated in rats as a treatment for learned cocaine addiction; However, another study in rats indicates that SCH-442416 upregulates expression of glutamate synthase (GS) and glutamate aspartate transporter (GAST) in Muller Cells which can exacerbate conditions such as Ocular Hypertension.
