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US Approved Rx

33

Other

21

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Primary Target

Estrogen receptor alpha

32

Estrogen receptor beta

29

Androgen Receptor

27

Steryl-sulfatase

26

Microtubule-associated protein 1A

2

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Highest Phase

Approved

32

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Approval Year

1940

26

Unknown

21

1931

2

1981

2

1937

1

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Condition

Unknown

27

Postmenopausal osteoporosis

26

Primary ovarian failure

26

Vaginal atrophy

26

Breast cancer

3

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Treatment Modality

Primary

29

Preventing

27

Palliative

4

Diagnostic

3

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CNS Activity

CNS Penetrant

31

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Originator

Upjohn

26

Bastian Werk, W. Germany

2

Butenandt, A.F.J.

2

Schering

1

Sequard, B.

1

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Substance Class

Chemical

44

Protein

9

Structurally Diverse

1

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Code System

FDA UNII

54

CAS

48

PUBCHEM

44

EPA CompTox

43

WIKIPEDIA

36

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Protein Type

ENZYME

2

RECEPTOR

1

TRANSPORTER

1

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ATC Level 1

GENITO URINARY SYSTEM AND SEX HORMONES

4

ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

2

BLOOD AND BLOOD FORMING ORGANS

1

VARIOUS

1

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ATC Level 2

SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM

4

ANTINEOPLASTIC AGENTS

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BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS

1

CONTRAST MEDIA

1

ENDOCRINE THERAPY

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ATC Level 3

ESTROGENS

3

HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE

2

ANDROGENS

1

ANDROGENS AND FEMALE SEX HORMONES IN COMBINATION

1

BLOOD AND RELATED PRODUCTS

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ATC Level 4

Natural and semisynthetic estrogens, plain

3

Progestogens and estrogens, fixed combinations

2

Progestogens and estrogens, sequential preparations

2

3-oxoandrosten (4) derivatives

1

Androgens and estrogens

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Substance Form

Principal Form

27

Salts, Hydrates, Esters, etc.

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Search results for "estradiol" in Related Substance Name (exact match)

Showing 11 - 20 of 54 results

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16.ALPHA.-HYDROXYESTRONE

JY611949JU

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Estrogen receptor

Conditions:

16alpha-hydroxyestrone is a naturally occurring estrone metabolite. It exerts estrogenic properties through covalent estrogen receptor (ER) binding. 16alpha-hydroxyestrone is a potential tumor initiator. The ratio 2-hydroxyestrone to 16alpha-hydroxye...

strone could serve as an innovative intermediate biomarker for breast cancer risk. This biomarker could be used to identify women at high risk, and provide the analytic framework for the development of new pharmaceutical and dietary intervention strategies.

.DELTA.6,7-ESTRADIOL

N4K670423X

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

6.ALPHA.-HYDROXYESTRADIOL

IL75Q4KU3Q

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Estrogen receptor beta

Estrogen receptor alpha

Conditions:

6α-Hydroxyestradiol is one of major metabolites of endogenous estrogens, as well as a positional isomer of estriol. Transformation of estradiol to 6α-Hydroxyestradiol is a major metabolic pathway of estradiol in the liver. CYP1A2 and CYP3A4 are the m...

ajor enzymes catalyzing the 6α-Hydroxyestradiol of estradiol.

ESTRADIOL PARAQUINOL

UR9WW8CA3J

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

4-HYDROXYESTRADIOL

C3ZO03450E

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

2-HYDROXYESTRONE

UQS3A06ILY

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

2-HYDROXYESTRADIOL

AYU2L67YUU

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

SEX HORMONE-BINDING GLOBULIN

YJ0ZSQ5NF5

Subunit 1 (373) Similarity Search Subunit 2 (373) Similarity Search

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Subunit 1 (373) Similarity Search Subunit 2 (373) Similarity Search

Status:

Other

Class:

PROTEIN

ESTROGEN RECEPTOR

SIDP85PFD6

Subunit 1 (595) Similarity Search

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Subunit 1 (595) Similarity Search

Status:

Other

Class:

PROTEIN

ANDROGEN RECEPTOR

EJC4C3UYXH

Subunit 1 (920) Similarity Search

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Subunit 1 (920) Similarity Search

Status:

Other

Class:

PROTEIN

Showing 11 - 20 of 54 results

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