Alfuzosin, a quinazoline derivative, acts as a selective and competitive antagonist of alpha 1-adrenoceptor-mediated contraction of prostatic, prostatic capsule, bladder base and proximal urethral smooth muscle, thereby reducing the tone of these structures. Consequently, urethral pressure and resistance, bladder outlet resistance, bladder instability and symptoms associated with benign prostatic hyperplasia are reduced. The two enantiomers (S and R) have the same pharmacological activity as the racemate. Ligand binding and functional studies demonstrate that the alpha1-antagonist properties of alfuzosin reside equally in its two enantiomers. Racemic alfuzosin is indicated for the symptomatic treatment of benign prostatic hyperplasia and adjunctive therapy in acute urinary retention.

Alfuzosin, a quinazoline derivative, acts as a selective and competitive antagonist of alpha 1-adrenoceptor-mediated contraction of prostatic, prostatic capsule, bladder base and proximal urethral smooth muscle, thereby reducing the tone of these structures. Consequently, urethral pressure and resistance, bladder outlet resistance, bladder instability and symptoms associated with benign prostatic hyperplasia are reduced. The two enantiomers (S and R) have the same pharmacological activity as the racemate. Ligand binding and functional studies demonstrate that the alpha1-antagonist properties of alfuzosin reside equally in its two enantiomers. Racemic alfuzosin is indicated for the symptomatic treatment of benign prostatic hyperplasia and adjunctive therapy in acute urinary retention.

2-Chloro-6,7-dimethoxy-4-quinazolinamine is building block for preparing terazosine and its analogues, α1-adrenoceptor antagonists

Alfuzosin is a quinazoline-derivative alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Alfuzosin is marketed in the United States by Sanofi Aventis under the brand name Uroxatral. UROXATRAL (alfuzosin HCl extended-release tablets) is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia. UROXATRAL is not indicated for the treatment of hypertension. Alfuzosin is a non-subtype specific alpha(1)-adrenergic blocking agent that exhibits selectivity for alpha(1)-adrenergic receptors in the lower urinary tract. Inhibition of these adrenoreceptors leads to the relaxation of smooth muscle in the bladder neck and prostate, resulting in the improvement in urine flow and a reduction in symptoms in benign prostate hyperplasia. Alfuzosin also inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.

Alfuzosin, a quinazoline derivative, acts as a selective and competitive antagonist of alpha 1-adrenoceptor-mediated contraction of prostatic, prostatic capsule, bladder base and proximal urethral smooth muscle, thereby reducing the tone of these structures. Consequently, urethral pressure and resistance, bladder outlet resistance, bladder instability and symptoms associated with benign prostatic hyperplasia are reduced. The two enantiomers (S and R) have the same pharmacological activity as the racemate. Ligand binding and functional studies demonstrate that the alpha1-antagonist properties of alfuzosin reside equally in its two enantiomers. Racemic alfuzosin is indicated for the symptomatic treatment of benign prostatic hyperplasia and adjunctive therapy in acute urinary retention.

Alfuzosin, a quinazoline derivative, acts as a selective and competitive antagonist of alpha 1-adrenoceptor-mediated contraction of prostatic, prostatic capsule, bladder base and proximal urethral smooth muscle, thereby reducing the tone of these structures. Consequently, urethral pressure and resistance, bladder outlet resistance, bladder instability and symptoms associated with benign prostatic hyperplasia are reduced. The two enantiomers (S and R) have the same pharmacological activity as the racemate. Ligand binding and functional studies demonstrate that the alpha1-antagonist properties of alfuzosin reside equally in its two enantiomers. Racemic alfuzosin is indicated for the symptomatic treatment of benign prostatic hyperplasia and adjunctive therapy in acute urinary retention.