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Details

Stereochemistry ACHIRAL
Molecular Formula C10H10ClN3O2
Molecular Weight 239.658
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 2-Chloro-6,7-dimethoxy-4-quinazolinamine

SMILES

COC1=C(OC)C=C2C(N)=NC(Cl)=NC2=C1

InChI

InChIKey=HWIIAAVGRHKSOJ-UHFFFAOYSA-N
InChI=1S/C10H10ClN3O2/c1-15-7-3-5-6(4-8(7)16-2)13-10(11)14-9(5)12/h3-4H,1-2H3,(H2,12,13,14)

HIDE SMILES / InChI
Molecular Formula C10H10ClN3O2
Molecular Weight 239.658
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/2863379

2-Chloro-6,7-dimethoxy-4-quinazolinamine is building block for preparing terazosine and its analogues, α1-adrenoceptor antagonists

Originator

Approval Year

Unknown
149124
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Development and validation of a reversed-phase HPLC method for monitoring of synthetic reactions during the manufacture of a key intermediate of an anti-hypertensive drug.
2006-10
Prediction of genotoxicity of chemical compounds by statistical learning methods.
2005-06
Patents

Patents

04251532
2
04351832
3
04483857
9

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 21:33:06 GMT 2025
Edited
by admin
on Mon Mar 31 21:33:06 GMT 2025
Record UNII
FG7Z4T71Y4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
2-Chloro-6,7-dimethoxy-4-quinazolinamine
Systematic Name English
ALFUZOSIN HYDROCHLORIDE IMPURITY B [EP IMPURITY]
Preferred Name English
4-AMINO-2-CHLORO-6,7-DIMETHOXYQUINAZOLINE
Systematic Name English
TERAZOSIN HYDROCHLORIDE DIHYDRATE IMPURITY A [EP IMPURITY]
Common Name English
2-CHLORO-4-AMINO-6,7-DIMETHOXYQUINAZOLINE
Systematic Name English
PRAZOSIN HYDROCHLORIDE IMPURITY A [EP IMPURITY]
Common Name English
DOXAZOSIN RELATED COMPOUND C [USP-RS]
Common Name English
4-QUINAZOLINAMINE, 2-CHLORO-6,7-DIMETHOXY-
Systematic Name English
DOXAZOSIN MESILATE IMPURITY F [EP IMPURITY]
Common Name English
2-CHLORO-6,7-DIMETHOXYQUINAZOLIN-4-AMINE
Systematic Name English
DOXAZOSIN RELATED COMPOUND C [USP IMPURITY]
Common Name English
QUINAZOLINE, 4-AMINO-2-CHLORO-6,7-DIMETHOXY-
Systematic Name English
Code System Code Type Description
ECHA (EC/EINECS)
245-821-7
Created by admin on Mon Mar 31 21:33:06 GMT 2025 , Edited by admin on Mon Mar 31 21:33:06 GMT 2025
PRIMARY
PUBCHEM
90235
Created by admin on Mon Mar 31 21:33:06 GMT 2025 , Edited by admin on Mon Mar 31 21:33:06 GMT 2025
PRIMARY
RS_ITEM_NUM
1225452
Created by admin on Mon Mar 31 21:33:06 GMT 2025 , Edited by admin on Mon Mar 31 21:33:06 GMT 2025
PRIMARY
EPA CompTox
DTXSID3057694
Created by admin on Mon Mar 31 21:33:06 GMT 2025 , Edited by admin on Mon Mar 31 21:33:06 GMT 2025
PRIMARY
FDA UNII
FG7Z4T71Y4
Created by admin on Mon Mar 31 21:33:06 GMT 2025 , Edited by admin on Mon Mar 31 21:33:06 GMT 2025
PRIMARY
CAS
23680-84-4
Created by admin on Mon Mar 31 21:33:06 GMT 2025 , Edited by admin on Mon Mar 31 21:33:06 GMT 2025
PRIMARY
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USP
NIH
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