2-Chloro-6,7-dimethoxy-4-quinazolinamine

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H10ClN3O2
Molecular Weight	239.658
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 2-Chloro-6,7-dimethoxy-4-quinazolinamine

Structure Search

SMILES

COC1=C(OC)C=C2C(N)=NC(Cl)=NC2=C1

InChI

InChIKey=HWIIAAVGRHKSOJ-UHFFFAOYSA-N

InChI=1S/C10H10ClN3O2/c1-15-7-3-5-6(4-8(7)16-2)13-10(11)14-9(5)12/h3-4H,1-2H3,(H2,12,13,14)

HIDE SMILES / InChI

Molecular Formula	C10H10ClN3O2
Molecular Weight	239.658
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9986714
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/2863379

2-Chloro-6,7-dimethoxy-4-quinazolinamine is building block for preparing terazosine and its analogues, α1-adrenoceptor antagonists

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Prediction of genotoxicity of chemical compounds by statistical learning methods.	2005 Jun	15962942
Development and validation of a reversed-phase HPLC method for monitoring of synthetic reactions during the manufacture of a key intermediate of an anti-hypertensive drug.	2006 Oct	17120814

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:33:06 GMT 2025` Edited by `admin` on `Mon Mar 31 21:33:06 GMT 2025`
Record UNII	FG7Z4T71Y4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

2-Chloro-6,7-dimethoxy-4-quinazolinamine

Systematic Name

English

ALFUZOSIN HYDROCHLORIDE IMPURITY B [EP IMPURITY]

Preferred Name

English

4-AMINO-2-CHLORO-6,7-DIMETHOXYQUINAZOLINE

Systematic Name

English

TERAZOSIN HYDROCHLORIDE DIHYDRATE IMPURITY A [EP IMPURITY]

Common Name

English

2-CHLORO-4-AMINO-6,7-DIMETHOXYQUINAZOLINE

Systematic Name

English

PRAZOSIN HYDROCHLORIDE IMPURITY A [EP IMPURITY]

Common Name

English

DOXAZOSIN RELATED COMPOUND C [USP-RS]

Common Name

English

4-QUINAZOLINAMINE, 2-CHLORO-6,7-DIMETHOXY-

Systematic Name

English

DOXAZOSIN MESILATE IMPURITY F [EP IMPURITY]

Common Name

English

2-CHLORO-6,7-DIMETHOXYQUINAZOLIN-4-AMINE

Systematic Name

English

DOXAZOSIN RELATED COMPOUND C [USP IMPURITY]

Common Name

English

QUINAZOLINE, 4-AMINO-2-CHLORO-6,7-DIMETHOXY-

Systematic Name

English

Code System Code Type Description

ECHA (EC/EINECS)

245-821-7