U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 11 - 20 of 1936 results

Cytochalasin B is a cell-permeable alkaloid, isolated from a fungus Helminthosporium dematioideum. Cytochalasin B is an inhibitor of actin polymerization through binding to the fast-growing (barbed) end of F-actin filaments. Cytochalasin is used in studies of actin polymerization, cell division, and cell movement. The compound also inhibits glucose transporters GLUT1,3 and 4 and was investigated in a clinical trial to prevent restenosis after angioplasty surgery.
Status:
Investigational
Source:
NCT01344148: Not Applicable Interventional Unknown status AIDS
(2009)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Designated
Source:
FDA ORPHAN DRUG:898222
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

TGF-B-recpotor inhibitor (dihydropyrrolopyrazole, 13) is one of the series of optimized, bioavailable dihydropyrrolopyrazole TGF-beta receptor type I inhibitors synthesized at Ely Lilly and is an investigational antitumor agent.
Status:
Designated
Source:
FDA ORPHAN DRUG:795820
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Designated
Source:
EU-Orphan Drug:EU/3/18/2106
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Designated
Source:
FDA ORPHAN DRUG:507215
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Echinocandin B is a naturally occurring antibiotic, isolated from Aspergillus nidulans. It acts as an inhibitor of fungal β-1,3-glucan synthase thereby disrupting the formation of the fungal cell wall. The drug itself was not developed in the clinic, but instead, it was used in the production of other echinocandin derivatives.
Status:
Designated
Source:
FDA ORPHAN DRUG:18887
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

B-Trisaccharide belongs to the class of organic compounds known as fatty acyl glycosides of mono- and disaccharides. B-Trisaccharide in blood group B is excreted when an individual is given Galactose. The B-trisaccharide was the only oligosaccharide detected in plasma after galactose administration to a blood-group-B secretor individual. The structure of the branched blood group B trisaccharide alone has been studied both by X-ray crystallography and by NMR.
Status:
Designated
Source:
FDA ORPHAN DRUG:625017
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Showing 11 - 20 of 1936 results