| Stereochemistry | ABSOLUTE |
| Molecular Formula | C29H37NO5 |
| Molecular Weight | 479.6078 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12[C@H](CC3=CC=CC=C3)NC(=O)[C@]14OC(=O)\C=C\[C@H](O)CCC[C@@H](C)C\C=C\[C@H]4[C@H](O)C(=C)[C@H]2C
InChI
InChIKey=GBOGMAARMMDZGR-TYHYBEHESA-N
InChI=1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
| Molecular Formula | C29H37NO5 |
| Molecular Weight | 479.6078 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Cytochalasin B is a cell-permeable alkaloid, isolated from a fungus Helminthosporium dematioideum. Cytochalasin B is an inhibitor of actin polymerization through binding to the fast-growing (barbed) end of F-actin filaments. Cytochalasin is used in studies of actin polymerization, cell division, and cell movement. The compound also inhibits glucose transporters GLUT1,3 and 4 and was investigated in a clinical trial to prevent restenosis after angioplasty surgery.
Originator
Approval Year
Doses
Sourcing
PubMed
Patents
Sample Use Guides
In a clinical trial for prevention of restenosis after angioplasty, cytochalasin B was administered locally at the site of angioplasty at a concentration of 0.1-8.0 ug/mL.
Route of Administration:
Intracoronary
2 uM cytochalasin B reduces the maximum rate of the viscosity change during the polymerization of actin. Viscosity was measured at low shear rates at 26°C in an inclined falling ball device. The reciprocal of the ball velocity is proportional to the absolute viscosity of Newtonian fluids. For non-Newtonian fluids, the observed ball velocity is used to calculate the apparent viscosity, given in centipoise (cp) for comparison with Newtonian fluids with the same ball velocity.