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Restrict the search for
pindolol
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Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
4-Hydroxyindole is a simple indole derivative. It effectively inhibits Abeta peptide-induced amyloid fibril formation and prevent cell death induced by the peptide in culture. 4-Hydroxyindole was glucuronidated mainly by UGT1A6, with minor activity by UGT1A9. 4-hydroxyindole is used for the synthesis of anti-inflammatory angular pyrrolocoumarins.
Status:
Possibly Marketed Outside US
Source:
BOPINDOLOL by Sandoz
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Bopindolol (4-[benzoyloxy-3-tertbutylaminopropoxy]-2-methylindole hydrogen malonate) is an indole beta-adrenoceptor antagonist bearing a benzoyl ester residue on the beta-carbon atom of the propanolamine side chain. Bopindolol is metabolized by esterase to benzoic acid and an active metabolite, 18-502
[4-(3-t-butylamino-2-hydroxypropoxy)-2-methyl indole], which is further metabolized to
20-785 [4-(3-t-butylaminopropoxy)-2-carboxyl indole]. Bopindolol produces sustained blockade of beta 1- and beta 2-adrenoceptors, has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol is used in the treatment of hypertension. In limited trials bopindolol has also successfully reduced symptoms in patients with angina pectoris, anxiety and essential tremor.
Status:
US Approved Rx
(2013)
First approved in 1958
Class:
MIXTURE
