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Restrict the search for
ethambutol
to a specific field?
Status:
Withdrawn
Source:
Ethylene dichloride
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Ethylene Dichloride is one of the most abundant synthetic chlorinated hydrocarbon used mainly as an intermediate in the production of vinyl chloride. Ethylene Dichloride is also used as a solvent in closed systems for various extraction and cleaning purposes in organic synthesis and as a dispersant in rubber and plastics, as a wetting and penetrating agent. Nearly 20 million tons of Ethylene Dichloride are produced in the United States, Western Europe, and Japan. Human exposure to Ethylene Dichloride occurs mostly via inhalation of vapors at industrial sites. Ethylene Dichloride is toxic (especially by inhalation due to its high vapor pressure), highly flammable, and possibly carcinogenic. Ethylene Dichloride acute intoxication in humans can produce acute renal failure that is associated with oliguria, albuminuria, and increased blood urea nitrogen concentrations.
Status:
US Approved Rx
(1999)
Source:
ANDA075095
(1999)
Source URL:
First approved in 1967
Source:
NDA016320
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
ETHAMBUTOL HYDROCHLORIDE is an oral chemotherapeutic agent which is specifically effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis. Ethambutol inhibits RNA synthesis and decreases tubercle bacilli replication. Nearly all strains of M. tuberculosis and M. kansasii as well as a number of strains of MAC are sensitive to ethambutol. Ethambutol inhibits arabinosyl transferases which is involved in cell wall biosynthesis. By inhibiting this enzyme, the bacterial cell wall complex production is inhibited. This leads to an increase in cell wall permeability. ETHAMBUTOL HCl is indicated for the treatment of pulmonary tuberculosis. It should not be used as the sole antituberculous drug, but should be used in conjunction with at least one other antituberculous drug.
Status:
US Approved Rx
(1999)
Source:
ANDA075095
(1999)
Source URL:
First approved in 1967
Source:
NDA016320
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
ETHAMBUTOL HYDROCHLORIDE is an oral chemotherapeutic agent which is specifically effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis. Ethambutol inhibits RNA synthesis and decreases tubercle bacilli replication. Nearly all strains of M. tuberculosis and M. kansasii as well as a number of strains of MAC are sensitive to ethambutol. Ethambutol inhibits arabinosyl transferases which is involved in cell wall biosynthesis. By inhibiting this enzyme, the bacterial cell wall complex production is inhibited. This leads to an increase in cell wall permeability. ETHAMBUTOL HCl is indicated for the treatment of pulmonary tuberculosis. It should not be used as the sole antituberculous drug, but should be used in conjunction with at least one other antituberculous drug.
