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Restrict the search for
decitabine
to a specific field?
Status:
Possibly Marketed Outside US
Source:
Octaplasma by Octapharma Pharmazeutika Produktionsges M B H [Canada]
Source URL:
First approved in 2013
Source:
BLA125416
Source URL:
Class:
MIXTURE
Status:
Investigational
Source:
NCT04609215: Phase 1/Phase 2 Interventional Recruiting Triple Negative Breast Cancer
(2020)
Source URL:
Class:
STRUCTURALLY DIVERSE
Status:
US Approved Rx
(2013)
Source:
ANDA203131
(2013)
Source URL:
First approved in 2006
Source:
DACOGEN by OTSUKA
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Decitabine was first synthesized by Pliml and Sorm in the Institute of Organic Chemistry, Czechoslovak Academy of Sciences in 1964. Later, the drug was approved by FDA for the treatment of myelodysplastic syndromes in patients with cancer. Upon administration the decitabine is metabolized to the active phosphorylated metabolite which is incorporated into DNA and thus inhibits DNA methyltransferase (decitabine deplete DNMT1).