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Development Status

Possibly Marketed Outside US

24

US Previously Marketed

13

Other

7

US Approved Allergenic Extract

2

US Approved OTC

1

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Primary Target

Apoptosis

2

A549

1

AKT/IRS/JNK signaling pathway

1

CYP3A

1

Cyclooxygenase-1

1

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Highest Phase

Approved

1

Phase I

1

Phase III

1

Phase IV

1

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Approval Year

1921

9

Unknown

8

2009

6

2010

4

1953

2

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Condition

Acute mountain sickness

1

Argentine hemorrhagic fever

1

Cancer

1

Cervical cancer

1

Chronic hepatitis

1

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Treatment Modality

Primary

5

Palliative

1

Preventing

1

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CNS Activity

CNS Active

2

CNS Non-penetrant

1

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Originator

Courbat, P. et al.

1

Knop, W.

1

Szent-Györgyi, A.

1

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Substance Class

Structurally Diverse

35

Chemical

5

Concept

5

Mixture

2

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GInAS Tag

KEW

4

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Code System

LIVERTOX

47

EVMPD

43

FDA UNII

42

DAILYMED

38

RXCUI

36

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ATC Level 1

ALIMENTARY TRACT AND METABOLISM

4

CARDIOVASCULAR SYSTEM

2

NERVOUS SYSTEM

2

GENITO URINARY SYSTEM AND SEX HORMONES

1

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ATC Level 2

DRUGS FOR CONSTIPATION

2

VASOPROTECTIVES

2

BILE AND LIVER THERAPY

1

DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS

1

OTHER GYNECOLOGICALS

1

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ATC Level 3

CAPILLARY STABILIZING AGENTS

2

DRUGS FOR CONSTIPATION

2

ANTI-DEMENTIA DRUGS

1

ANTISPASMODICS IN COMBINATION WITH PSYCHOLEPTICS

1

BELLADONNA AND DERIVATIVES, PLAIN

1

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ATC Level 4

Contact laxatives

2

Belladonna alkaloids, tertiary amines

1

Belladonna and derivatives in combination with psycholeptics

1

Bioflavonoids

1

Liver therapy

1

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Substance Form

Principal Form

40

Salts, Hydrates, Esters, etc.

2

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Search results for "LiverTox|HDS in comments (approximate match)

Showing 11 - 20 of 47 results

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BALSAM PERU

8P5F881OCY

Status:

US Approved Allergenic Extract (1994)

First marketed in 1921

Class:

STRUCTURALLY DIVERSE

SENNA LEAF

AK7JF626KX

Status:

US Previously Marketed

First approved in 2009

Class:

STRUCTURALLY DIVERSE

ST. JOHN'S WORT

UFH8805FKA

Status:

US Previously Marketed

First approved in 2001

Class:

STRUCTURALLY DIVERSE

RAUWOLFIA SERPENTINA

H192N84N1G

Status:

US Previously Marketed

First approved in 1953

Class:

STRUCTURALLY DIVERSE

BLACK COHOSH

K73E24S6X9

Status:

US Previously Marketed

First marketed in 1921

Class:

STRUCTURALLY DIVERSE

PIPER METHYSTICUM ROOT

BOW48C81XP

Status:

US Previously Marketed

First marketed in 1921

Class:

STRUCTURALLY DIVERSE

Piper methysticum (Kava) root is consumed in a wide range of Pacific Ocean societies, from coastal areas of New Guinea to Polynesian Hawaii. Kava drinking was an integral part of the religious, social, political and economic life of Pacific islands s...

ocieties. Kava was also used as an important ingredient in the traditional medicine of many Pacific Islands societies. Kava beverage was regarded as having sedative activity, able to soothe the nerves, relax the mind and body, induce refreshing sleep and to ease the pain. Kava lactones have demonstrated sedative and anxiolytic activity in clinical trials. In addition to sedative activity, Western traditional indications of Kava (dried root, infusion, and aqueous ethanol extract) include infection and inflammation of the genitourinary tract, neuralgia, bronchitis, dyspepsia, dysmenorrhoea and rheumatism. A major constituent of Kava root is the resin which contains kava lactones. The major kava lactones are kavain, dihydrokavain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin. Other constituents include flavokavins and chalcone pigments. Extracts are often standardized for kava lactone content.

VALERIAN

JWF5YAW3QW

Status:

US Previously Marketed

First marketed in 1921

Class:

STRUCTURALLY DIVERSE

GUARANA

52U584F1CA

Status:

US Previously Marketed

First marketed in 1921

Class:

STRUCTURALLY DIVERSE

ATROPA BELLADONNA

WQZ3G9PF0H

Status:

US Previously Marketed

First marketed in 1921

Class:

STRUCTURALLY DIVERSE

SAW PALMETTO

J7WWH9M8QS

Status:

US Previously Marketed

First marketed in 1921

Class:

STRUCTURALLY DIVERSE

Showing 11 - 20 of 47 results

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