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Restrict the search for
m nalidixic acid
to a specific field?
Class (Stereo):
CHEMICAL (RACEMIC)
Pranidipine is the calcium channel blocker. Pranidipine did not affect the sensitivity of the contractile proteins to calcium. Pranidipine also did not alter cyclic GMP-induced relaxation in alpha-toxin-skinned vascular preparations. Pranidipine also prolonged glyceryl trinitrate-induced relaxation in the endothelium denuded rat aorta. Pranidipine enhances cyclic GMP-independent NO-induced relaxation of smooth muscle by a mechanism other than through NO-induced hyperpolarization. These effects were in direct contrast to amlodipine, another new 1,4-dihydropyridine calcium antagonist. Pranidipine increased blood velocity and probably blood flow in the optic nerve head, choroid, and retina of rabbits. Pranidipine was not detrimental to global cardiac function in animals with dilated cardiomyopathy. Pranidipine enhances relaxation produced by endothelium-derived relaxing factor in carotid artery. Pranidipine was investigated as pharmacological agent for the treatment of angina pectoris and hypertension.
Class (Stereo):
CHEMICAL (MIXED)
Nileprost is a prostacyclin analogue stabilized by introduction of the cyano group at its 5-position. Nileprost is a mixed type PGI2/PGE2 agonist. The development of the prostaglandin analogue nileprost [ZK 34798] for use in peptic ulcers has been discontinued at phase II by Schering AG in Germany.
Status:
Investigational
Source:
INN:monalazone disodium [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Monalazone is a sulfonylbenzoic acid derivative used as vaginal disinfectant or antiseptic and spermicidal contraceptive.
Class (Stereo):
CHEMICAL (RACEMIC)
Furaprofen (also known as R-803), a nonsteroidal drug possesses anti-inflammatory properties. This drug was studied for the treatment of rheumatoid arthritis. However, information about the further development of this drug is not available.
Status:
Investigational
Source:
NCT01063920: Phase 2/Phase 3 Interventional Completed Osteoarthritis
(2010)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of the non-steroidal anti-inflammatory drug (NSAID) naproxen that is hydrolysed to pharmacologically active naproxen once absorbed. Naproxen etemesil was in development with Logical Therapeutics for the treatment of osteoarthritis. However, no recent development has been reported. It is also in phase I clinical trials for the treatment of inflammation and arthritis.The compound was originally developed by Medinox, licensed to Logical Therapeutics in 2006 for partial rights.
Class (Stereo):
CHEMICAL (ACHIRAL)
Phetharbital (Pyrictal), a barbiturate with virtually no hypnotic side effects, was originally introduced for the management of epilepsy and has since been shown to have powerful hepatic enzyme-inducing properties. In preliminary clinical studies, phetharbital was found to be effective against febrile seizures, minor myoclonic seizures and in petit mal. Phetharbital is relatively ineffective in the control of the tonic extensor seizure pattern and would not be expected to modify grand mal tonic seizures. Chronic administration of phetharbital causes an increased excretion of 6 beta-hydroxycortisol in human urine. This increase in 6 beta-hydroxycortisol excretion is not accompanied by an increase in the 17-hydroxycorticosteroids levels in urine, indicating that an increased adrenal output of cortisol is not responsible for the increased urinary levels of 6 beta hydroxycortisol. Phetharbital was also effective in the rare severe unconjugated hyperbilirubinemia of the Crigler-Najjar syndrome.
Status:
Investigational
Source:
NCT00937937: Phase 2 Interventional Active, not recruiting Acral Lentiginous Melanoma
(2009)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Dinaciclib (SCH 727965) is a small molecule inhibitor of cyclin-dependent kinases. Dinaciclib demostrates potent and selective inhibition of CDK2, CDK5, CDK1, and CDK9 activity. Dinaciclib inhibits cell cycle progression and proliferation in various tumor cell lines in vitro. Dinaciclib is a product of a drug discovery collaboration between Pharmacopeia (later Ligand Pharmaceuticals) and Schering-Plough (later Merck & Co.) that began in 1998. Dinaciclib showed promising effect in treating haematological malignancies and solid tumors.
Class (Stereo):
CHEMICAL (RACEMIC)
Vincofos is a broad-spectrum canine anthelmintic. All or nearly all of the ascarids, hookworms, whipworms, and the tapeworm, Taenia pisiformis, were expelled following therapy with vincofos. The tapeworm, Dipylidium caninum, was also effectively removed by the vincofos treatment, but it appeared that a slightly greater dosage would be required to obtain maximum anthelmintic effect.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Class (Stereo):
CHEMICAL (MIXED)
Rioprostil is a methylprostaglandin E1 analog. Rioprostil inhibits gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. In peptic ulcer cases, it facilitates the healing process and the elimination of pain. Rioprostil can also be used to prevent recurrence of duodenal ulcers. However, its development has been discontinued in 2000.
