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Restrict the search for
m didanosine
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Desacetoxymatricarin is a sesquiterpene lactone found in the genus Artemisia and in the form of 8-hydroxy and acetoxy derivatives in the genus Achillea. The formation of desacetoxymatricarin from (+)-costunolide probably involves more than one enzyme, including a cytochrome P450 enzyme. It is a potent 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitor. Desacetoxymatricarin showed the highest anti-hypercholesterolemic potential. Oligvon, a preparation containing desacetoxymatricarin, is used to prevent and treat artherosclerosis.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
(S)-Seliciclib is enantiomer of the potent cyclin-dependent kinase (CDK) inhibitor Roscovitine. Roscovitine (racemic mixture) is an inhibitor of cell cyclin-dependent kinase (CDK)-2, CDK-4 and CDK-5, which are upregulated in stress conditions inducing apoptosis. (S)-Seliciclib potently inhibits Cyclin-dependent kinase 1. In vivo studies in rabbits demonstrated that both isomers (R- and S-) significantly reduce intraocular pressure (IOP). However, S- isomer was superior to R- isomer in lowering IOP and providing protection to retinal ganglionic cells.
