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Restrict the search for
aminosalicylic acid
to a specific field?
Class (Stereo):
CHEMICAL (ACHIRAL)
Iotetric Acid is triiodobenzoic acid derivative with potential application as neutrophil imaging in diagnosis of cystic fibrosis.
Class (Stereo):
CHEMICAL (RACEMIC)
Pirazmonam is a potent anti-gram-negative monobactam that is differentiated from aztreonam by its high intrinsic activity against Ps. aeruginosa and good activity against Pseudomonas species. Pirazmonam has generally poor activity against gram-positive aerobic bacteria and anaerobic bacteria. Pirazmonam is a Trojan Horse molecule containing a b-lactam antibiotic that has been developed based on bacterial iron uptake systems. It features high structural similarity to aztreonam attached to a 3-hydroxy-4-pyridinone iron chelating group. Pirazmonam exhibited strong affinity to penicillin-binding protein 3 (PBP3) of Escherichia coli and moderate to negligible affinity to the other E. coli PBPs.
Status:
Investigational
Source:
INN:persilic acid [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Persilic acid is a virucide, hemostatic, capillary protective agent. 0.1% aqueous solution of K salt is used as a fluorescent acid-base indicator.
Status:
Investigational
Source:
NCT01640808: Phase 3 Interventional Completed Hepatic Neoplasm Malignant Recurrent
(2012)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Peretinoin is an orally available, acyclic retinoid with potential antineoplastic and chemopreventive activities. Peretinoin binds to and activates nuclear retinoic acid receptors (RAR), which in turn recruit coactivator proteins and promote, with other transcriptional complexes, the transcription of target genes. As a result, this agent may modulate the expression of genes involved in the regulation of cell proliferation, cell differentiation, and apoptosis of both normal and tumor cells. Peretinoin inhibits post-therapeutic recurrence of hepatocellular carcinoma via unclear mechanisms. The European Commission granted Orphan Drug designation for Kowa's peretinoin to treat hepatocellular carcinoma (HCC).
Class (Stereo):
CHEMICAL (ACHIRAL)
Cinnamaverine is an aminodiphenylacrylate, a smooth muscle relaxant and antispasmodic with some local anesthetic activity.
Status:
Investigational
Source:
NCT01644682: Phase 3 Interventional Completed Cost-effective and Sustainable Vector Control Methods Will be Established to Reduce VL in India, Bangladesh and Nepal
(2012)
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Class (Stereo):
CHEMICAL (MIXED)
Difebarbamate is a barbituric acid derivative. It is a hypnotic drug. Difebarbamate is a component of Tetrabamate complex, which was introduced for clinical use in the treatment of alcoholism and various types of drug dependence. After oral administration of difebarbamate, the compound was completely metabolized and three metabolic pathways were observed: oxidation of Cl of the n-butyl chain which leads to the oxygen dealkylation; hydrolysis of the carbamoyloxy group; oxidation of the benzene ring in position 4. Tetrabamate can induce hepatotoxicity, probably due to an idiosyncratic metabolic mechanism. Despite restrictions on its indications and treatment duration introduced in 1997, cases of severe liver damage have continued to be notified in France.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Dazoxiben is a selective inhibitor of thromboxane synthetase (IC50 3 nM), an enzyme that converts the endo-peroxide PGH2 into thromboxane A2, which is a potent vasoconstrictor and platelet aggregating agent. Dazoxiben has demonstrated efficacy in some clinical trial for the treatment of Raynaud's syndrome, an ischaemic condition manifested by the pallor of affected digits. In subsequent studies, however, no significant effect of dazoxiben was found. Dazoxiben was also evaluated in patients with sepsis, adult respiratory distress syndrome, stable angina, and other conditions.
Class (Stereo):
CHEMICAL (ACHIRAL)
Dazoquinast is an imidazoquinoxaline derivative with antiallergic properties, developed by the British company Roussel Laboratories Ltd. Dazoquinast inhibited the IgE-mediated passive cutaneous anaphylaxis in rats passively sensitized to ovalbumen after intravenous and oral administration with ED50s of 0.073 and 0.13 mg/kg respectively.
Status:
Investigational
Source:
INN:loreclezole [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Loreclezole was found to be active in all animal models of seizures, whether a genetic model of reflex epilepsy was used or models where seizures were elicited by chemical or electrical stimulation. In addition, loreclezole was active against both TON and CLON seizures and increased the threshold for behavioral as well as EEG seizures. Loreclezole has a very rapid onset of action and a duration of the activity, which in certain tests last for more than 24 hr. Chronic administration for 5-7 days did not lead to tolerance to the anticonvulsant action of loreclezole. Loreclezole potentiates gamma-aminobutyric acid (GABA) type A receptor function, by interacting with a specific allosteric modulatory site on receptor beta-subunits. It also acts as a negative modulator at a novel regulatory site, enhancing GABAA receptor sensitization. Inhibits homomeric ρ1 GABAC receptors.
