Details
Stereochemistry | ACHIRAL |
Molecular Formula | C12H12N2O3 |
Molecular Weight | 232.2353 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=CC=C(OCCN2C=CN=C2)C=C1
InChI
InChIKey=XQGZSYKGWHUSDH-UHFFFAOYSA-N
InChI=1S/C12H12N2O3/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14/h1-6,9H,7-8H2,(H,15,16)
Dazoxiben is a selective inhibitor of thromboxane synthetase (IC50 3 nM), an enzyme that converts the endo-peroxide PGH2 into thromboxane A2, which is a potent vasoconstrictor and platelet aggregating agent. Dazoxiben has demonstrated efficacy in some clinical trial for the treatment of Raynaud's syndrome, an ischaemic condition manifested by the pallor of affected digits. In subsequent studies, however, no significant effect of dazoxiben was found. Dazoxiben was also evaluated in patients with sepsis, adult respiratory distress syndrome, stable angina, and other conditions.
Approval Year
PubMed
Title | Date | PubMed |
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Study of the mechanisms involved in the bradykinin-induced contraction of the pig iris sphincter muscle in vitro. | 2003 Jan 1 |
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Effects of camonagrel, a selective inhibitor of platelet thromboxane synthase, on the platelet-subendothelium interaction. | 2003 Sep |
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Chronic AT(1) receptor blockade alters mechanisms mediating responses to hypoxia in rat skeletal muscle resistance arteries. | 2004 Aug |
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Role of endothelin-1 and thromboxane A2 in the pulmonary hypertension induced by heparin-protamine interaction in anesthetized dogs. | 2004 Jan |
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BK2 but not BK1 receptors mediating contractile response in human umbilical arteries: role of thromboxane A2. | 2004 May |
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Attenuation of lipopolysaccharide-induced hyperreactivity of human internal mammary arteries by melatonin. | 2004 Sep |
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Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin. | 2005 Nov |
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C029166
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SUB06925MIG
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C171920
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53001
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DB03052
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100000083448
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78218-09-4
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DAZOXIBEN
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DTXSID9045639
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09ZFC7974Q
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5130
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CHEMBL267473
Created by
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)