DAZOQUINAST

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H7N3O2
Molecular Weight	213.1922
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C1=CN2C(C=NC3=CC=CC=C23)=N1

InChI

InChIKey=JVKYTWZLUFMIKS-UHFFFAOYSA-N

InChI=1S/C11H7N3O2/c15-11(16)8-6-14-9-4-2-1-3-7(9)12-5-10(14)13-8/h1-6H,(H,15,16)

HIDE SMILES / InChI

Molecular Formula	C11H7N3O2
Molecular Weight	213.1922
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2897466

Dazoquinast is an imidazoquinoxaline derivative with antiallergic properties, developed by the British company Roussel Laboratories Ltd. Dazoquinast inhibited the IgE-mediated passive cutaneous anaphylaxis in rats passively sensitized to ovalbumen after intravenous and oral administration with ED50s of 0.073 and 0.13 mg/kg respectively.

Originator

Approval Year

PubMed

Title	Date	PubMed
Synthesis and oral antiallergic activity of carboxylic acids derived from imidazo[2,1-c][1,4]benzoxazines, imidazo[1,2-a]quinolines, imidazo[1,2-a]quinoxalines, imidazo[1,2-a]quinoxalinones, pyrrolo[1,2-a]quinoxalinones, pyrrolo[2,3-a]quinoxalinones, and imidazo[2,1-b]benzothiazoles.	1988 Jun	2897466

Patents

Sample Use Guides

In Vivo Use Guide

ED50 in rats 0.073 mg/kg after intravenous and 0.13 mg/kg after oral administration.

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:35:41 GMT 2023` Edited by `admin` on `Fri Dec 15 16:35:41 GMT 2023`
Record UNII	A16F9MIN3Z
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DAZOQUINAST

Official Name

English

dazoquinast [INN]

Common Name

English

IMIDAZO(1,2-A)QUINOXALINE-2-CARBOXYLIC ACID

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29712