U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 151 - 160 of 170 results

Estradiol benzoate is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors. This agent exhibits mild anabolic and metabolic properties, and increases blood coagulability. Although estradiol benzoate is not approved by the FDA for use in humans in the United States, it is approved for veterinary use as a subdermal implant both alone (CELERIN®) and in combination with the anabolic steroid trenbolone acetate (SYNOVEX® Plus).
Status:
First marketed in 1921
Source:
Emulsion of Cod Liver Oil with Calcium Phosphate N.F.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Phosphate is a major intracellular anion in mammals. Hydrogen phopshate is a protonated form of phosphate. In serum, phosphate exists in two forms, dihydrogen phosphate (H2PO4) and its salt, mono-hydrogen phosphate (HPO4). At the physiologic pH of 7.40, the pK of H2PO4 is 6.8 and the ratio of HPO4 to H2PO4 is 4:1. Altered level of phosphate can be an indicator of various disorders, such as chronic renal failure, hypoparathyroidism, familial intermittent hyperphosphatemia, endocrine disorders, hyperthyroidism, acromegaly, juvenile hypogonadism, etc. These disorders may lead to either hyper- or hypophosphatemia, which can be caused by cellular shifts of phosphate. Patients with hypophosphatemia can be treated with dietary phosphate supplements (potassium phosphate, for example).
Status:
Investigational
Source:
INN:piriprost
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Piriprost (U-60, 257) is a structural analog of prostaglandin I2 (PGI2) with low IP receptor-mediated activity. It inhibits 5-LO (5-lipoxygenase). Piriprost inhibits the release of histamine and leukotrienes, implicating its role in inflammation and allergic responses. However, it was shown, that piriprost did not influence the airway responses after allergen in asthma. Nevertheless, even more, the drug was irritant to the respiratory tract than was placebo.
Status:
Investigational
Source:
INN:doxibetasol
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Doxybetasol is the corticosteroid. It is an impurity of Betamethasone, which is a glucocorticoid used as an anti-inflammatory agent. Doxybetasol also has anti-inflammatory and anti-allergic properties.
Status:
US Previously Marketed
Source:
Quilene by Warner /Chilcott
(1969)
Source URL:
First approved in 1969
Source:
Quilene by Warner /Chilcott
Source URL:

Class (Stereo):
CHEMICAL (MIXED)

Conditions:

PENTAPIPERIUM is a synthetic quaternary ammonium anticholinergic and the antisecretory agent used especially in the treatment of peptic ulcer.
Status:
US Previously Marketed
Source:
Neodrol by Pfizer
(1953)
Source URL:
First approved in 1953
Source:
Neodrol by Pfizer
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


STANOLONE, also known as dihydrotestosterone, is a potent androgenic metabolite of testosterone and anabolic agent for systemic use. It may be used as a replacement of male sex steroids in men who have androgen deficiency, for example as a result of the loss of both testes, and also the treatment of certain rare forms of aplastic anemia which are or may be responsive to anabolic androgens.

Showing 151 - 160 of 170 results