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Restrict the search for
methylene blue
to a specific field?
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Loprazolam is a hypnotic drug which stimulates GABA-A receptors. Due to its hypnotic activity the drug is used to treat short-term sleep disordes.
Status:
Possibly Marketed Outside US
Source:
Benezrial by Houde [France]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Guanoxabenz is an antihypertensive drug that was in clinical use in the 1980s. It acts as a selective agonist of alpha2A1 and alpha2B1 adrenergic receptors. Guanoxabenz is the main metabolite of the FDA-approved drug guanabenz.
Status:
Possibly Marketed Outside US
Source:
Azumolene sodium by ZYF Pharm Chemical
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Azumolene is a direct-acting, skeletal muscle relaxant with structural similarities to dantrolene. It is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene inhibits a component of store-operated calcium entry (SOCE) coupled to activation of type 1 ryanodine receptor (RyR1) by caffeine and ryanodine, whereas the SOCE component induced by thapsigargin is not affected. Azumolene distinguishes between two mechanisms of cellular signaling to SOCE in skeletal muscle, one that is coupled to and one independent from RyR1. Azumolene is equipotent to dantrolene sodium in blocking pharmacologic-induced muscle contractures and that azumolene is efficacious for treatment/prevention of malignant hyperthermia.
Status:
Discontinued
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Oftasceine is a fluorescent dye or luminescent agent. It was recommended for the use as an effective agent for the blood-retinal barrier integrity studies. It was used to detect drug interactions with multidrug resistance proteins because it is an effective substrate of the multidrug resistance transporter 1P-glycoprotein and the multidrug resistance-related protein. The Oftasceine assay can be used as a quantitative, standardized, inexpensive screening test in a routine clinical laboratory setting. The assay detects both P-glycoprotein and multidrug resistance-associated protein activities, and identifies acute myeloid leukaemia patients with unfavorable therapy responses. It is used in ophthalmic solutions as a staining agent when fitting hydrogel contact lens. The use of a fluorexon dye-impregnated strip (pre-wetted with preservative-free saline) yielded comparable results with a fluorescein strip for assessments of tear film stability based on tear film break-up time.
Status:
Withdrawn
Source:
Furaguanidin
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Furaguanidine (guanofuracin) is a derivative of nitrofuran. It was formerly used as an anti-infective agent, for the treatment of bacillary dysentery, enteritis, and other intestinal infections, and topically to treat skin and mucous membrane infections. The compound was shown to irreversibly inactivate the trypanothione reductase from Trypanosoma cruzi in anaerobic conditions.
Status:
Investigational
Source:
NCT03406364: Phase 1 Interventional Completed Solid Tumor
(2018)
Source URL:
Class:
MIXTURE
Status:
Investigational
Source:
NCT04440202: Not Applicable Interventional Completed Cardiometabolic Health
(2021)
Source URL:
Class:
MIXTURE
Status:
Investigational
Source:
NCT02982525: Not Applicable Interventional Completed Cardiovascular Disease
(2016)
Source URL:
Class:
MIXTURE
Status:
Investigational
Source:
NCT02204709: Not Applicable Interventional Terminated Obesity
(2015)
Source URL:
Class:
MIXTURE
Status:
Other
Class:
MIXTURE
