GUANOXABENZ

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H8Cl2N4O
Molecular Weight	247.081
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of GUANOXABENZ

Structure Search

SMILES

ONC(=N)N\N=C\C1=C(Cl)C=CC=C1Cl

InChI

InChIKey=QKIQJNNDIWGVEH-UUILKARUSA-N

InChI=1S/C8H8Cl2N4O/c9-6-2-1-3-7(10)5(6)4-12-13-8(11)14-15/h1-4,15H,(H3,11,13,14)/b12-4+

HIDE SMILES / InChI

Molecular Formula	C8H8Cl2N4O
Molecular Weight	247.081
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7258704 | https://www.ncbi.nlm.nih.gov/pubmed/7914222 | https://www.ncbi.nlm.nih.gov/pubmed/9351903

Guanoxabenz is an antihypertensive drug that was in clinical use in the 1980s. It acts as a selective agonist of alpha2A1 and alpha2B1 adrenergic receptors. Guanoxabenz is the main metabolite of the FDA-approved drug guanabenz.

Approval Year

PubMed

PubMed

Title	Date	PubMed
Neuropharmacological studies in rodents on the action of RX 781094, a new selective alpha 2-adrenoceptor antagonist.	1983 Jun	6136932

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:42:09 GMT 2023` Edited by `admin` on `Fri Dec 15 15:42:09 GMT 2023`
Record UNII	P9HIK5V7WK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GUANOXABENZ

Official Name

English

GUANOXABENZ [USAN]

Common Name

English

GUANOXABENZ [MI]

Common Name

English

1-[(2,6-Dichlorobenzylidene)amino]-3-hydroxyguanidine

Systematic Name

English

43-663

Code

English

HYDRAZINECARBOXIMIDAMIDE, 2-((2,6-DICHLOROPHENYL)METHYLENE)-N-HYDROXY-

Systematic Name

English

Guanoxabenz [WHO-DD]

Common Name

English

guanoxabenz [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29709

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

WHO-ATC

C02CC07

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

WHO-VATC

QC02CC07

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

Code System Code Type Description

EPA CompTox

DTXSID101027553

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

PRIMARY

WIKIPEDIA

GUANOXABENZ

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

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CAS

24047-25-4

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

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ChEMBL

CHEMBL461343

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

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PUBCHEM

9567831

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

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NCI_THESAURUS

C77298

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

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SMS_ID

100000077879

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

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EVMPD

SUB14038MIG

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

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MESH

C028782

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

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FDA UNII

P9HIK5V7WK

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

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INN

3615

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

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DRUG BANK

DB13410

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

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MERCK INDEX

m5872

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

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Merck Index

DRUG CENTRAL

1345

Created by admin on Fri Dec 15 15:42:09 GMT 2023 , Edited by admin on Fri Dec 15 15:42:09 GMT 2023

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