LOPRAZOLAM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H21ClN6O3
Molecular Weight	464.904
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCN(CC1)\C=C2/N=C3CN=C(C4=CC=CC=C4Cl)C5=C(C=CC(=C5)[N+]([O-])=O)N3C2=O

InChI

InChIKey=UTEFBSAVJNEPTR-RGEXLXHISA-N

InChI=1S/C23H21ClN6O3/c1-27-8-10-28(11-9-27)14-19-23(31)29-20-7-6-15(30(32)33)12-17(20)22(25-13-21(29)26-19)16-4-2-3-5-18(16)24/h2-7,12,14H,8-11,13H2,1H3/b19-14-

HIDE SMILES / InChI

Description
Sources: www.mhra.gov.uk/home/groups/par/documents/websiteresources/con418469.pdf
Curator's Comment: description was created based on several sources, including, http://home.intekom.com/pharm/hmr/dormnoct.html

Loprazolam is a hypnotic drug which stimulates GABA-A receptors. Due to its hypnotic activity the drug is used to treat short-term sleep disordes.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABA-A receptor; benzodiazepine site 38 Target ID: CHEMBL2109243 Sources: www.mhra.gov.uk/home/groups/par/documents/websiteresources/con418469.pdf	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Short term slep problems 3 Sources: http://home.intekom.com/pharm/hmr/dormnoct.html	Primary		Approved 8429	DORMONOCT Approved Use Short-term treatment of insomnia.Sleep disturbances in the geriatric patient. Pre-operative sleep disturbances.

PubMed

Title	Date	PubMed
A comparison of the hypnotic activity of loprazolam, temazepam and placebo in general practice.	1984	6141114

Patents

Sample Use Guides

In Vivo Use Guide

The usual adult dose is 1 - 2 mg at bedtime.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

LOPRAZOLAM

Official Name

English

loprazolam [INN]

Common Name

English

(Z)-6-(O-CHLOROPHENYL)-2,4-DIHYDRO-2-((4-METHYL-1-PIPERAZINYL)METHYLENE)-8-NITRO-1H-IMIDAZO(1,2-A)(1,4)BENZODIAZEPIN-1-ONE

Common Name

English

(2Z)-6-(2-CHLOROPHENYL)-2,4-DIHYDRO-2-((4-METHYL-1-PIPERAZINYL)METHYLENE)-8-NITRO-1H-IMIDAZO(1,2-A)(1,4)BENZODIAZEPIN-1-ONE

Systematic Name

English

TRIAZULENONE, (Z)-

Common Name

English

1H-IMIDAZO(1,2-A)(1,4)BENZODIAZEPIN-1-ONE, 6-(2-CHLOROPHENYL)-2,4-DIHYDRO-2-((4-METHYL-1-PIPERAZINYL)METHYLENE)-8-NITRO-, (2Z)-

Systematic Name

English

RU-31158 FREE BASE

Code

English

LOPRAZOLAM [MI]

Common Name

English

TRIAZULENONE, (Z)-ISOMER

Common Name

English

TRIAZULENONE

Common Name

English

Loprazolam [WHO-DD]

Common Name

English

Classification Tree Code System Code

DEA NO.

2773