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Details

Stereochemistry ACHIRAL
Molecular Formula C23H21ClN6O3
Molecular Weight 464.904
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of LOPRAZOLAM

SMILES

CN1CCN(CC1)\C=C2/N=C3CN=C(C4=CC=CC=C4Cl)C5=C(C=CC(=C5)[N+]([O-])=O)N3C2=O

InChI

InChIKey=UTEFBSAVJNEPTR-RGEXLXHISA-N
InChI=1S/C23H21ClN6O3/c1-27-8-10-28(11-9-27)14-19-23(31)29-20-7-6-15(30(32)33)12-17(20)22(25-13-21(29)26-19)16-4-2-3-5-18(16)24/h2-7,12,14H,8-11,13H2,1H3/b19-14-

HIDE SMILES / InChI

Description
Sources: www.mhra.gov.uk/home/groups/par/documents/websiteresources/con418469.pdf
Curator's Comment: description was created based on several sources, including, http://home.intekom.com/pharm/hmr/dormnoct.html

Loprazolam is a hypnotic drug which stimulates GABA-A receptors. Due to its hypnotic activity the drug is used to treat short-term sleep disordes.

CNS Activity

CNS Active
3913
Curator's Comment: The drug is hypnotic.

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
GABA-A receptor; benzodiazepine site
38
Target ID: CHEMBL2109243
Sources: www.mhra.gov.uk/home/groups/par/documents/websiteresources/con418469.pdf
Agonist
2678
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
DORMONOCT

Approved Use

Short-term treatment of insomnia.Sleep disturbances in the geriatric patient. Pre-operative sleep disturbances.
PubMed

PubMed

TitleDatePubMed
A comparison of the hypnotic activity of loprazolam, temazepam and placebo in general practice.
1984
Patents

Patents

US4044142 A
3

Sample Use Guides

In Vivo Use Guide
The usual adult dose is 1 - 2 mg at bedtime.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
LOPRAZOLAM
INN   MI   WHO-DD  
INN  
Official Name English
loprazolam [INN]
Common Name English
(Z)-6-(O-CHLOROPHENYL)-2,4-DIHYDRO-2-((4-METHYL-1-PIPERAZINYL)METHYLENE)-8-NITRO-1H-IMIDAZO(1,2-A)(1,4)BENZODIAZEPIN-1-ONE
Common Name English
(2Z)-6-(2-CHLOROPHENYL)-2,4-DIHYDRO-2-((4-METHYL-1-PIPERAZINYL)METHYLENE)-8-NITRO-1H-IMIDAZO(1,2-A)(1,4)BENZODIAZEPIN-1-ONE
Systematic Name English
TRIAZULENONE, (Z)-
Common Name English
1H-IMIDAZO(1,2-A)(1,4)BENZODIAZEPIN-1-ONE, 6-(2-CHLOROPHENYL)-2,4-DIHYDRO-2-((4-METHYL-1-PIPERAZINYL)METHYLENE)-8-NITRO-, (2Z)-
Systematic Name English
RU-31158 FREE BASE
Code English
LOPRAZOLAM [MI]
Common Name English
TRIAZULENONE, (Z)-ISOMER
Common Name English
TRIAZULENONE
Common Name English
Loprazolam [WHO-DD]
Common Name English
Classification Tree Code System Code
DEA NO. 2773
Created by admin on Fri Dec 15 15:46:09 GMT 2023 , Edited by admin on Fri Dec 15 15:46:09 GMT 2023
WHO-VATC QN05CD11
Created by admin on Fri Dec 15 15:46:09 GMT 2023 , Edited by admin on Fri Dec 15 15:46:09 GMT 2023
NCI_THESAURUS C1012
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WHO-ATC N05CD11
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Code System Code Type Description
FDA UNII
759N8462G8
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PRIMARY
EPA CompTox
DTXSID30894873
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PRIMARY
NCI_THESAURUS
C66032
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PRIMARY
PUBCHEM
3033860
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PRIMARY
INN
4884
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PRIMARY
MERCK INDEX
m6901
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PRIMARY Merck Index
DRUG CENTRAL
1602
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PRIMARY
RXCUI
38555
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PRIMARY RxNorm
CAS
61197-73-7
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PRIMARY
EVMPD
SUB08576MIG
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PRIMARY
SMS_ID
100000082009
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PRIMARY
WIKIPEDIA
LOPRAZOLAM
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PRIMARY
DRUG BANK
DB13643
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PRIMARY
MESH
C020168
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PRIMARY
ChEMBL
CHEMBL2107448
Created by admin on Fri Dec 15 15:46:09 GMT 2023 , Edited by admin on Fri Dec 15 15:46:09 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of LOPRAZOLAM
SALT/SOLVATE (PARENT)
Structure of LOPRAZOLAM MESILATE
NIH
NCATS
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